Detailed information of TA system TA049909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1032743..1033271
• Replicon: chromosome
• Accession: NZ_CP009829
• Organism: Xylella fastidiosa strain 3124

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFC3_RS04445
• Protein ID: WP_023906426.1
• Coordinates: 1032990..1033271 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A1S0V873
• Locus tag: XFC3_RS04440
• Protein ID: WP_023906425.1
• Coordinates: 1032743..1033003 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFC3_RS04430	1028498..1031560	+	3063	WP_023906423.1	efflux RND transporter permease subunit	-
XFC3_RS04435	1031606..1032412	+	807	WP_023906424.1	oxidoreductase	-
XFC3_RS04440	1032743..1033003	+	261	WP_023906425.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFC3_RS04445	1032990..1033271	+	282	WP_023906426.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFC3_RS04450	1033689..1034723	-	1035	WP_023906427.1	serine protease	-
XFC3_RS04455	1034729..1034977	-	249	WP_199251119.1	transposase	-
XFC3_RS04460	1035506..1035784	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
XFC3_RS04465	1035772..1036068	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFC3_RS04470	1036725..1036967	+	243	WP_010894524.1	type II toxin-antitoxin system ParD family antitoxin	-
XFC3_RS04475	1036960..1037248	+	289	Protein_867	type II toxin-antitoxin system RelE/ParE family toxin	-
XFC3_RS04480	1037710..1038144	+	435	Protein_868	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10697.42 Da
• Isoelectric Point: 9.0869

>T49909 WP_023906426.1 NZ_CP009829:1032990-1033271 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALVGNWKDLRDCHIKPDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T49909 NZ_CP009829:1032990-1033271 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAGGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGGTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCCCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8983.55 Da
• Isoelectric Point: 10.5972

>AT49909 WP_023906425.1 NZ_CP009829:1032743-1033003 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT49909 NZ_CP009829:1032743-1033003 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCGTTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V873