Detailed information of TA system TA049899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875546..876078
• Replicon: chromosome
• Accession: NZ_CP009828
• Organism: Staphylococcus aureus strain MS4

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: NI36_RS04195
• Protein ID: WP_001103942.1
• Coordinates: 875758..876078 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: NI36_RS04190
• Protein ID: WP_001058486.1
• Coordinates: 875546..875755 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NI36_RS04145	870566..871786	-	1221	WP_000266157.1	site-specific integrase	-
NI36_RS04150	871874..872602	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
NI36_RS04155	872626..873354	-	729	WP_058142969.1	staphylococcal enterotoxin type Q	-
NI36_RS04160	873424..873855	-	432	WP_001228759.1	hypothetical protein	-
NI36_RS04165	873872..874330	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
NI36_RS04170	874342..874674	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
NI36_RS04175	874867..875130	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
NI36_RS04180	875123..875395	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
NI36_RS04185	875407..875553	+	147	WP_000784875.1	hypothetical protein	-
NI36_RS04190	875546..875755	+	210	WP_001058486.1	hypothetical protein	Antitoxin
NI36_RS04195	875758..876078	+	321	WP_001103942.1	DUF1474 family protein	Toxin
NI36_RS04200	876142..877011	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
NI36_RS04205	877028..878497	+	1470	WP_000390454.1	virulence-associated E family protein	-
NI36_RS04210	878783..879145	+	363	WP_001039168.1	hypothetical protein	-
NI36_RS04215	879147..879431	+	285	WP_000998181.1	hypothetical protein	-
NI36_RS04220	879428..880069	+	642	WP_001019764.1	hypothetical protein	-
NI36_RS04225	880586..880927	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	852531..885878	33347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T49899 WP_001103942.1 NZ_CP009828:875758-876078 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T49899 NZ_CP009828:875758-876078 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT49899 WP_001058486.1 NZ_CP009828:875546-875755 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT49899 NZ_CP009828:875546-875755 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4