Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 857851..858328 Replicon chromosome
Accession NZ_CP009828
Organism Staphylococcus aureus strain MS4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag NI36_RS04040 Protein ID WP_000052076.1
Coordinates 857851..858039 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag NI36_RS04045 Protein ID WP_001059690.1
Coordinates 858068..858328 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI36_RS04010 853889..854359 + 471 WP_000824462.1 hypothetical protein -
NI36_RS04015 854700..855386 + 687 WP_001823812.1 thermonuclease family protein -
NI36_RS04020 855743..855943 + 201 WP_001059082.1 cold-shock protein -
NI36_RS04025 856442..856660 - 219 WP_000005888.1 hypothetical protein -
NI36_RS04030 856722..857006 - 285 WP_001004397.1 hypothetical protein -
NI36_RS04035 857094..857663 - 570 WP_001106657.1 hypothetical protein -
NI36_RS04040 857851..858039 - 189 WP_000052076.1 hypothetical protein Toxin
NI36_RS04045 858068..858328 - 261 WP_001059690.1 hypothetical protein Antitoxin
NI36_RS04050 858669..858872 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
NI36_RS04055 858869..859105 - 237 WP_000368687.1 hypothetical protein -
NI36_RS04060 859330..859911 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
NI36_RS04065 859984..860601 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
NI36_RS04070 860757..861251 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
NI36_RS04075 861650..862072 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
NI36_RS04080 862220..862936 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 852531..885878 33347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-286)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T49898 WP_000052076.1 NZ_CP009828:c858039-857851 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T49898 NZ_CP009828:c858039-857851 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT49898 WP_001059690.1 NZ_CP009828:c858328-858068 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT49898 NZ_CP009828:c858328-858068 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References