Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/ElaA-DUF1778
Location 21915..22669 Replicon plasmid pXF39
Accession NZ_CP009827
Organism Xylella fastidiosa strain Pr8x

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag XFPR_RS12145 Protein ID WP_023908224.1
Coordinates 22184..22669 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag XFPR_RS12140 Protein ID WP_023908223.1
Coordinates 21915..22187 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFPR_RS12090 17480..17677 + 198 WP_023908215.1 hypothetical protein -
XFPR_RS12095 17837..17989 - 153 WP_088572720.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
XFPR_RS12100 18063..18305 + 243 WP_051372742.1 hypothetical protein -
XFPR_RS12105 18362..18679 + 318 WP_143704198.1 hypothetical protein -
XFPR_RS12110 18665..19222 - 558 WP_031337221.1 recombinase family protein -
XFPR_RS12115 19281..19583 - 303 WP_023908220.1 hypothetical protein -
XFPR_RS12120 19734..20153 - 420 WP_023908221.1 putative toxin-antitoxin system toxin component, PIN family -
XFPR_RS12125 20153..20392 - 240 WP_023908222.1 ribbon-helix-helix domain-containing protein -
XFPR_RS12130 20825..21145 + 321 WP_004091397.1 type II toxin-antitoxin system RelE/ParE family toxin -
XFPR_RS12135 21275..21601 + 327 WP_004091396.1 DNA-binding protein -
XFPR_RS12140 21915..22187 + 273 WP_023908223.1 DUF1778 domain-containing protein Antitoxin
XFPR_RS12145 22184..22669 + 486 WP_023908224.1 GNAT family N-acetyltransferase Toxin
XFPR_RS12150 22663..23154 + 492 WP_051372743.1 thermonuclease family protein -
XFPR_RS12155 24054..25445 - 1392 WP_075584705.1 relaxase/mobilization nuclease domain-containing protein -
XFPR_RS12160 25430..25996 - 567 WP_075584706.1 plasmid mobilization relaxosome protein MobC -
XFPR_RS12165 26197..26586 + 390 WP_023908230.1 hypothetical protein -
XFPR_RS12170 26583..27290 + 708 WP_023908231.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..39580 39580
- flank IS/Tn - - 18665..19222 557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-148)

Antitoxin

Vibrio phage ICP1, Orf50

(3-85)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17845.66 Da        Isoelectric Point: 9.6931

>T49896 WP_023908224.1 NZ_CP009827:22184-22669 [Xylella fastidiosa]
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRRALTNHLNGASRTFVVVDANQYVLGYYALAAGSVAHQEATRAIRLNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQSIAENVGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F

Download         Length: 486 bp

>T49896 NZ_CP009827:22184-22669 [Xylella fastidiosa]
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTCGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGACGCGCATTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTTGTTGTCGATGCCAACC
AGTACGTGCTTGGGTACTACGCTTTGGCAGCTGGGTCTGTCGCGCATCAAGAGGCCACGCGTGCTATCCGACTTAATATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGTTGGCTGTGGATACTCGCGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTGCAGTCCATTGCAGAGAACGTCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10251.77 Da        Isoelectric Point: 4.7419

>AT49896 WP_023908223.1 NZ_CP009827:21915-22187 [Xylella fastidiosa]
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLDAPQDTNLGLNRLMA
IKAPWSIGNT

Download         Length: 273 bp

>AT49896 NZ_CP009827:21915-22187 [Xylella fastidiosa]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGCGGTTCCGGCAATTCACTGTGTTGCTTGATGCGCCACAAGACACCAATCTCGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCGGCAATACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References