Detailed information of TA system TA049895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2632280..2632888
• Replicon: chromosome
• Accession: NZ_CP009826
• Organism: Xylella fastidiosa strain Pr8x

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFPR_RS11860
• Protein ID: WP_196432211.1
• Coordinates: 2632592..2632888 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9P9V8
• Locus tag: XFPR_RS11855
• Protein ID: WP_010895177.1
• Coordinates: 2632280..2632588 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFPR_RS11820	2628129..2628368	-	240	WP_157288615.1	hypothetical protein	-
XFPR_RS11825	2628863..2629624	-	762	WP_010895174.1	Bax inhibitor-1/YccA family protein	-
XFPR_RS11850	2630820..2632214	+	1395	WP_088572712.1	hypothetical protein	-
XFPR_RS11855	2632280..2632588	-	309	WP_010895177.1	putative addiction module antidote protein	Antitoxin
XFPR_RS11860	2632592..2632888	-	297	WP_196432211.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFPR_RS11865	2632975..2633745	+	771	WP_023908175.1	hypothetical protein	-
XFPR_RS11870	2633877..2634128	-	252	WP_031337190.1	hypothetical protein	-
XFPR_RS11875	2634349..2634743	-	395	Protein_2316	DUF596 domain-containing protein	-
XFPR_RS11880	2634755..2635084	-	330	Protein_2317	DUF769 domain-containing protein	-
XFPR_RS11885	2635232..2635621	-	390	WP_031337193.1	DUF596 domain-containing protein	-
XFPR_RS11890	2635626..2636870	-	1245	WP_023908178.1	DUF769 domain-containing protein	-
XFPR_RS11895	2637265..2637642	-	378	WP_023908179.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2630820..2634011	3191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-97)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11317.07 Da
• Isoelectric Point: 10.1713

>T49895 WP_196432211.1 NZ_CP009826:c2632888-2632592 [Xylella fastidiosa]
IYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDKS
TQQSDIRRAIELAKSLED

Nucleotide

• Length: 297 bp

>T49895 NZ_CP009826:c2632888-2632592 [Xylella fastidiosa]
ATCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCTCAT
CAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGCGCGAAC
ACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAGTCA
ACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11038.60 Da
• Isoelectric Point: 4.6561

>AT49895 WP_010895177.1 NZ_CP009826:c2632588-2632280 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Nucleotide

• Length: 309 bp

>AT49895 NZ_CP009826:c2632588-2632280 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V409