Detailed information of TA system TA049894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 2136304..2137100
• Replicon: chromosome
• Accession: NZ_CP009826
• Organism: Xylella fastidiosa strain Pr8x

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: -
• Locus tag: XFPR_RS09825
• Protein ID: WP_023907999.1
• Coordinates: 2136304..2136915 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A0A060HF63
• Locus tag: XFPR_RS09830
• Protein ID: WP_004087046.1
• Coordinates: 2136912..2137100 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFPR_RS09780	2131696..2131986	-	291	WP_023907990.1	hypothetical protein	-
XFPR_RS09785	2132107..2133219	-	1113	WP_031336988.1	Bro-N domain-containing protein	-
XFPR_RS09790	2133422..2133805	-	384	WP_023907991.1	hypothetical protein	-
XFPR_RS09795	2133802..2134050	-	249	WP_031336990.1	hypothetical protein	-
XFPR_RS09800	2134047..2134235	-	189	WP_023907993.1	hypothetical protein	-
XFPR_RS09805	2134296..2134577	-	282	WP_023907994.1	hypothetical protein	-
XFPR_RS09810	2134679..2135050	+	372	WP_023907996.1	hypothetical protein	-
XFPR_RS09815	2135230..2135475	-	246	WP_023907997.1	hypothetical protein	-
XFPR_RS09820	2135474..2136253	+	780	WP_023907998.1	helix-turn-helix transcriptional regulator	-
XFPR_RS09825	2136304..2136915	-	612	WP_023907999.1	Fic/DOC family protein	Toxin
XFPR_RS09830	2136912..2137100	-	189	WP_004087046.1	antitoxin VbhA family protein	Antitoxin
XFPR_RS09835	2137502..2137906	+	405	Protein_1923	hypothetical protein	-
XFPR_RS09840	2138227..2138685	+	459	WP_023908001.1	hypothetical protein	-
XFPR_RS09845	2138685..2139086	+	402	WP_023908002.1	hypothetical protein	-
XFPR_RS09850	2139083..2139274	+	192	WP_023908003.1	hypothetical protein	-
XFPR_RS09855	2139318..2139845	+	528	WP_075584676.1	hypothetical protein	-
XFPR_RS09860	2139964..2140155	+	192	WP_023908006.1	hypothetical protein	-
XFPR_RS09865	2140176..2140550	+	375	WP_023908007.1	hypothetical protein	-
XFPR_RS09870	2140570..2141391	+	822	WP_023908008.1	YfdQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2102564..2167206	64642

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22919.68 Da
• Isoelectric Point: 4.9434

>T49894 WP_023907999.1 NZ_CP009826:c2136915-2136304 [Xylella fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKEQFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIRDGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T49894 NZ_CP009826:c2136915-2136304 [Xylella fastidiosa]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGCCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCAATTTTTGTGTGGCCTTGATGCTGAGGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACAGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGCGGATTGGC
TAGTATCATCCGCGATGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6855.80 Da
• Isoelectric Point: 4.9859

>AT49894 WP_004087046.1 NZ_CP009826:c2137100-2136912 [Xylella fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA

Nucleotide

• Length: 189 bp

>AT49894 NZ_CP009826:c2137100-2136912 [Xylella fastidiosa]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A060HF63