Detailed information of TA system TA049892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1826463..1827004
• Replicon: chromosome
• Accession: NZ_CP009826
• Organism: Xylella fastidiosa strain Pr8x

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: XFPR_RS08350
• Protein ID: WP_031336866.1
• Coordinates: 1826463..1826786 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: Q9PCB8
• Locus tag: XFPR_RS08355
• Protein ID: WP_010894329.1
• Coordinates: 1826783..1827004 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFPR_RS08310	1821985..1822206	+	222	WP_162009296.1	hypothetical protein	-
XFPR_RS08315	1822388..1822714	-	327	WP_010893744.1	hypothetical protein	-
XFPR_RS08320	1823030..1823347	-	318	WP_010893743.1	hypothetical protein	-
XFPR_RS08330	1824232..1824576	-	345	Protein_1632	hypothetical protein	-
XFPR_RS08335	1824706..1825887	+	1182	WP_023907867.1	replication initiation factor domain-containing protein	-
XFPR_RS08340	1825874..1826206	+	333	WP_010894326.1	hypothetical protein	-
XFPR_RS08345	1826219..1826374	+	156	WP_155114993.1	hypothetical protein	-
XFPR_RS08350	1826463..1826786	-	324	WP_031336866.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
XFPR_RS08355	1826783..1827004	-	222	WP_010894329.1	antitoxin MazE family protein	Antitoxin
XFPR_RS08360	1827290..1827718	-	429	WP_031336868.1	DUF3693 domain-containing protein	-
XFPR_RS08365	1827863..1828168	+	306	WP_143704181.1	hypothetical protein	-
XFPR_RS08370	1828179..1828487	+	309	WP_143704182.1	hypothetical protein	-
XFPR_RS08375	1828480..1828746	+	267	WP_075584657.1	hypothetical protein	-
XFPR_RS08380	1828750..1828932	+	183	WP_023907871.1	hypothetical protein	-
XFPR_RS08385	1829080..1829277	-	198	WP_023907872.1	hypothetical protein	-
XFPR_RS08390	1829378..1830553	+	1176	WP_060870321.1	replication initiation factor domain-containing protein	-
XFPR_RS08395	1830594..1830905	+	312	WP_075584660.1	hypothetical protein	-
XFPR_RS08400	1831031..1831282	+	252	WP_023907875.1	hypothetical protein	-
XFPR_RS08405	1831302..1831430	+	129	WP_011097859.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1821600..1836608	15008

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (9-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11771.81 Da
• Isoelectric Point: 7.9848

>T49892 WP_031336866.1 NZ_CP009826:c1826786-1826463 [Xylella fastidiosa]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVALCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Nucleotide

• Length: 324 bp

>T49892 NZ_CP009826:c1826786-1826463 [Xylella fastidiosa]
ATGATTCAACGTGGCGACCTTGTAACAGTTTCCCTACAAGGCGACTACGGCAAGCCTAGACCAGCGTTGATCGTTCAATC
AGACCTTCTAACGGAGTTAGATAGTGTCGCACTGTGTCCGGTCACGAGCGACCTGCGGAATGCGATATTTCGTGTCACCG
TTGAACCAACTGCGGCCAATGGTTTACGGACACTGTCGCAGGTCATGGTAGATAAAATTTCAACACTACCACGTAACAAA
ATCAGCGAACCTTTTGGACGTCTCAATGACGAGAGAATGAAAGCAATAGAAAGAGCATTGTTACTAATTATTGGTATCAT
TTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8426.53 Da
• Isoelectric Point: 7.3606

>AT49892 WP_010894329.1 NZ_CP009826:c1827004-1826783 [Xylella fastidiosa]
MTSTHRPDSKIVHHREQMRAAGLRPVQLWVPDTRTPEFAAEIQSQCRALKGDQAEADALRFTEKAMTHIEDWK

Nucleotide

• Length: 222 bp

>AT49892 NZ_CP009826:c1827004-1826783 [Xylella fastidiosa]
ATGACATCAACTCACAGACCAGACAGCAAGATAGTTCACCACAGGGAACAAATGCGCGCAGCTGGATTGCGTCCTGTGCA
GCTCTGGGTACCGGATACGCGCACACCGGAATTCGCTGCTGAAATTCAAAGCCAGTGCCGCGCCCTGAAAGGCGACCAGG
CAGAAGCCGACGCTTTACGCTTCACAGAAAAAGCCATGACCCATATTGAAGATTGGAAATGA

Structures

Antitoxin

• AlphaFold DB: Q9PCB8