Detailed information of TA system TA049891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1395135..1395727
• Replicon: chromosome
• Accession: NZ_CP009826
• Organism: Xylella fastidiosa strain Pr8x

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: Q9PD07
• Locus tag: XFPR_RS06245
• Protein ID: WP_010894094.1
• Coordinates: 1395135..1395431 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: XFPR_RS06250
• Protein ID: WP_004085592.1
• Coordinates: 1395434..1395727 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFPR_RS06215	1390664..1391155	-	492	WP_171817079.1	glutathione peroxidase	-
XFPR_RS06220	1391614..1391775	-	162	WP_010894100.1	hypothetical protein	-
XFPR_RS06225	1391994..1392869	+	876	WP_023906641.1	ABC transporter ATP-binding protein	-
XFPR_RS06230	1392866..1393846	+	981	WP_023907674.1	hypothetical protein	-
XFPR_RS06235	1394088..1394534	+	447	WP_031336674.1	hypothetical protein	-
XFPR_RS06240	1394724..1394943	-	220	Protein_1215	tail fiber protein	-
XFPR_RS06245	1395135..1395431	+	297	WP_010894094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFPR_RS06250	1395434..1395727	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
XFPR_RS06255	1395783..1396136	-	354	WP_023907675.1	hypothetical protein	-
XFPR_RS06260	1396133..1396774	-	642	WP_023907676.1	hypothetical protein	-
XFPR_RS06265	1396771..1397601	-	831	WP_088572692.1	hypothetical protein	-
XFPR_RS06270	1397598..1397915	-	318	WP_060870277.1	hypothetical protein	-
XFPR_RS06275	1397915..1398685	-	771	WP_023907680.1	hypothetical protein	-
XFPR_RS06280	1398733..1399023	+	291	WP_196432179.1	CopG family transcriptional regulator	-
XFPR_RS06285	1399007..1399273	+	267	WP_023907681.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1395135..1419913	24778

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.73 Da
• Isoelectric Point: 9.8173

>T49891 WP_010894094.1 NZ_CP009826:1395135-1395431 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQQRGDTIYLLLCGGDKG
LQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T49891 NZ_CP009826:1395135-1395431 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCACGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCAGCGTGGCGACACGATCTACTTGCTACTTTGCGGCGGTGACAAAGGA
TTACAAGCGCGTGACATCAAGACTGCGCTGCACCTCTCTGAACAATGGAGCGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT49891 WP_004085592.1 NZ_CP009826:1395434-1395727 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT49891 NZ_CP009826:1395434-1395727 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCGGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCCGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACGACATTAGCC
GTGATGAAGGCGCTAGGGATCGAGCTCTCTGCGAAACCGTCTGGTGTTCACTGA

Structures

Toxin

• AlphaFold DB: A0A1S0V711