Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1043261..1043823 Replicon chromosome
Accession NZ_CP009826
Organism Xylella fastidiosa strain Pr8x

Toxin (Protein)


Gene name parE Uniprot ID Q9PBR6
Locus tag XFPR_RS04525 Protein ID WP_010894527.1
Coordinates 1043527..1043823 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9PBR5
Locus tag XFPR_RS04520 Protein ID WP_010894528.1
Coordinates 1043261..1043539 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFPR_RS04490 1039355..1040161 + 807 WP_023907555.1 oxidoreductase -
XFPR_RS04495 1040491..1040751 + 261 WP_010894534.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
XFPR_RS04500 1040738..1041019 + 282 WP_023907556.1 type II toxin-antitoxin system YafQ family toxin -
XFPR_RS04505 1041437..1041799 - 363 WP_143704175.1 hypothetical protein -
XFPR_RS04510 1041819..1042478 - 660 WP_023907557.1 hypothetical protein -
XFPR_RS04515 1042484..1042732 - 249 WP_196432191.1 transposase -
XFPR_RS04520 1043261..1043539 + 279 WP_010894528.1 CopG family ribbon-helix-helix protein Antitoxin
XFPR_RS04525 1043527..1043823 + 297 WP_010894527.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFPR_RS04530 1044480..1044722 + 243 WP_010894524.1 type II toxin-antitoxin system ParD family antitoxin -
XFPR_RS04535 1044715..1045003 + 289 Protein_879 type II toxin-antitoxin system RelE/ParE family toxin -
XFPR_RS04540 1045465..1045899 + 435 Protein_880 hypothetical protein -
XFPR_RS04545 1046308..1046763 + 456 WP_010894521.1 hypothetical protein -
XFPR_RS04550 1046760..1047032 + 273 WP_010894520.1 hypothetical protein -
XFPR_RS04555 1047036..1047344 + 309 WP_010894519.1 type II toxin-antitoxin system RelE/ParE family toxin -
XFPR_RS04560 1047453..1047722 + 270 WP_010894518.1 hypothetical protein -
XFPR_RS04565 1047774..1047977 + 204 WP_023906434.1 hypothetical protein -
XFPR_RS04570 1047971..1048506 + 536 Protein_886 recombinase family protein -
XFPR_RS04575 1048536..1048745 - 210 WP_010894516.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11155.72 Da        Isoelectric Point: 7.4670

>T49890 WP_010894527.1 NZ_CP009826:1043527-1043823 [Xylella fastidiosa]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS

Download         Length: 297 bp

>T49890 NZ_CP009826:1043527-1043823 [Xylella fastidiosa]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10772.08 Da        Isoelectric Point: 5.6126

>AT49890 WP_010894528.1 NZ_CP009826:1043261-1043539 [Xylella fastidiosa]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG

Download         Length: 279 bp

>AT49890 NZ_CP009826:1043261-1043539 [Xylella fastidiosa]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S0VAK4

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V821

References