Detailed information of TA system TA049889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1040491..1041019
• Replicon: chromosome
• Accession: NZ_CP009826
• Organism: Xylella fastidiosa strain Pr8x

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFPR_RS04500
• Protein ID: WP_023907556.1
• Coordinates: 1040738..1041019 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q9PBQ9
• Locus tag: XFPR_RS04495
• Protein ID: WP_010894534.1
• Coordinates: 1040491..1040751 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFPR_RS04485	1036247..1039309	+	3063	WP_023907554.1	efflux RND transporter permease subunit	-
XFPR_RS04490	1039355..1040161	+	807	WP_023907555.1	oxidoreductase	-
XFPR_RS04495	1040491..1040751	+	261	WP_010894534.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFPR_RS04500	1040738..1041019	+	282	WP_023907556.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFPR_RS04505	1041437..1041799	-	363	WP_143704175.1	hypothetical protein	-
XFPR_RS04510	1041819..1042478	-	660	WP_023907557.1	hypothetical protein	-
XFPR_RS04515	1042484..1042732	-	249	WP_196432191.1	transposase	-
XFPR_RS04520	1043261..1043539	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
XFPR_RS04525	1043527..1043823	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFPR_RS04530	1044480..1044722	+	243	WP_010894524.1	type II toxin-antitoxin system ParD family antitoxin	-
XFPR_RS04535	1044715..1045003	+	289	Protein_879	type II toxin-antitoxin system RelE/ParE family toxin	-
XFPR_RS04540	1045465..1045899	+	435	Protein_880	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10726.55 Da
• Isoelectric Point: 10.0987

>T49889 WP_023907556.1 NZ_CP009826:1040738-1041019 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALLGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAKLGL

Nucleotide

• Length: 282 bp

>T49889 NZ_CP009826:1040738-1041019 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGCTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGAAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8997.58 Da
• Isoelectric Point: 10.5972

>AT49889 WP_010894534.1 NZ_CP009826:1040491-1040751 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTISDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT49889 NZ_CP009826:1040491-1040751 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCATTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: Q9PBQ9