Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 26357..27059 | Replicon | plasmid pXF51-J1 |
| Accession | NZ_CP009825 | ||
| Organism | Xylella fastidiosa strain J1a12 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | - |
| Locus tag | OY18_RS14050 | Protein ID | WP_042464090.1 |
| Coordinates | 26357..26743 (+) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | - |
| Locus tag | OY18_RS14055 | Protein ID | WP_023908247.1 |
| Coordinates | 26724..27059 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OY18_RS14005 (OY18_13195) | 21709..21972 | - | 264 | WP_088569753.1 | DUF4190 domain-containing protein | - |
| OY18_RS14010 (OY18_13200) | 22037..22363 | - | 327 | WP_010895223.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| OY18_RS14015 (OY18_13205) | 22350..22580 | - | 231 | WP_042464041.1 | hypothetical protein | - |
| OY18_RS14020 (OY18_13210) | 22860..23141 | - | 282 | WP_088569754.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS14025 (OY18_13215) | 23150..23317 | - | 168 | WP_042464043.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS14030 (OY18_13220) | 23305..23558 | - | 254 | Protein_29 | CopG family ribbon-helix-helix protein | - |
| OY18_RS14035 (OY18_13225) | 23818..24837 | - | 1020 | WP_010895227.1 | hypothetical protein | - |
| OY18_RS14040 (OY18_13230) | 25198..25954 | - | 757 | Protein_31 | alpha/beta hydrolase | - |
| OY18_RS14045 (OY18_13235) | 26124..26246 | - | 123 | Protein_32 | recombinase family protein | - |
| OY18_RS14050 (OY18_13240) | 26357..26743 | + | 387 | WP_042464090.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OY18_RS14055 (OY18_13245) | 26724..27059 | + | 336 | WP_023908247.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| OY18_RS14060 (OY18_13250) | 27214..27813 | - | 600 | WP_010895232.1 | conjugal transfer protein TrbN | - |
| OY18_RS15330 | 27819..28115 | - | 297 | WP_229926373.1 | conjugal transfer protein | - |
| OY18_RS14065 (OY18_13255) | 28123..29232 | - | 1110 | WP_229926374.1 | P-type conjugative transfer protein TrbL | - |
| OY18_RS14070 (OY18_13260) | 29236..29472 | - | 237 | WP_010894503.1 | EexN family lipoprotein | - |
| OY18_RS14075 (OY18_13265) | 29489..30262 | - | 774 | WP_042464049.1 | P-type conjugative transfer protein TrbJ | - |
| OY18_RS14080 (OY18_13270) | 30281..31687 | - | 1407 | WP_088569755.1 | TrbI/VirB10 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..51180 | 51180 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14170.35 Da Isoelectric Point: 9.7274
>T49888 WP_042464090.1 NZ_CP009825:26357-26743 [Xylella fastidiosa]
MPSWSIIEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQRGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRTVYTVKFT
EAVFVLHCFQKKSKSGVATPKVDMNIIRARLKVAEALAQELRNAKTNH
MPSWSIIEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQRGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRTVYTVKFT
EAVFVLHCFQKKSKSGVATPKVDMNIIRARLKVAEALAQELRNAKTNH
Download Length: 387 bp
>T49888 NZ_CP009825:26357-26743 [Xylella fastidiosa]
ATGCCATCATGGTCGATAATAGAGAAACCGCTCGAATGGATCGCGAGCAGCTACAAGGATCTGATGGCGTTGCCGCCCGA
CGTGCGCCGGCGGTTTGGTTACGCGCTGTCGCTGGCACAGAGGGGCGACCAGGATGACGCGGCCAAGGTGCTCAAGGGCT
TCGGCGGGGCGGGCGTACTGGAAGTCGTCGAAGACGATGCCGGTGGCACGTACCGGACGGTCTACACGGTGAAGTTCACG
GAAGCCGTGTTCGTCCTGCATTGCTTCCAGAAGAAGAGCAAGAGCGGGGTCGCCACGCCAAAGGTGGACATGAACATCAT
CCGTGCTCGGCTGAAGGTAGCCGAGGCACTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
ATGCCATCATGGTCGATAATAGAGAAACCGCTCGAATGGATCGCGAGCAGCTACAAGGATCTGATGGCGTTGCCGCCCGA
CGTGCGCCGGCGGTTTGGTTACGCGCTGTCGCTGGCACAGAGGGGCGACCAGGATGACGCGGCCAAGGTGCTCAAGGGCT
TCGGCGGGGCGGGCGTACTGGAAGTCGTCGAAGACGATGCCGGTGGCACGTACCGGACGGTCTACACGGTGAAGTTCACG
GAAGCCGTGTTCGTCCTGCATTGCTTCCAGAAGAAGAGCAAGAGCGGGGTCGCCACGCCAAAGGTGGACATGAACATCAT
CCGTGCTCGGCTGAAGGTAGCCGAGGCACTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12265.39 Da Isoelectric Point: 10.0997
>AT49888 WP_023908247.1 NZ_CP009825:26724-27059 [Xylella fastidiosa]
MQKRIIEGVEVQRSSGNVFADLGLHDAEKLKIKTGLVIEIRKAMHALGLNQQEAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPVGHLTLATA
MQKRIIEGVEVQRSSGNVFADLGLHDAEKLKIKTGLVIEIRKAMHALGLNQQEAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPVGHLTLATA
Download Length: 336 bp
>AT49888 NZ_CP009825:26724-27059 [Xylella fastidiosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAACGCAGCTCGGGCAACGTCTTCGCCGACTTGGGACTGCATGACGC
CGAAAAACTCAAGATCAAGACCGGGCTGGTGATCGAGATCAGGAAGGCGATGCACGCCCTCGGGCTGAATCAGCAAGAGG
CGGCGAAACGCATGGGTATCCCGCAACCGAAGGTGTCGGGCATGATGCGTGGCGACTTCACCAACTTGTCCGAACGCAAG
CTGATGGACTGCCTGAATCGCCTCGGCTACGACATCGAGATCAAGGTACGGCCGGCCGCTGAGCCGGTCGGGCATCTGAC
GCTCGCAACCGCATGA
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAACGCAGCTCGGGCAACGTCTTCGCCGACTTGGGACTGCATGACGC
CGAAAAACTCAAGATCAAGACCGGGCTGGTGATCGAGATCAGGAAGGCGATGCACGCCCTCGGGCTGAATCAGCAAGAGG
CGGCGAAACGCATGGGTATCCCGCAACCGAAGGTGTCGGGCATGATGCGTGGCGACTTCACCAACTTGTCCGAACGCAAG
CTGATGGACTGCCTGAATCGCCTCGGCTACGACATCGAGATCAAGGTACGGCCGGCCGCTGAGCCGGTCGGGCATCTGAC
GCTCGCAACCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|