Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacT-ataR/ElaA-DUF1778 |
| Location | 20471..21225 | Replicon | plasmid pXF51-J1 |
| Accession | NZ_CP009825 | ||
| Organism | Xylella fastidiosa strain J1a12 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q9PHI0 |
| Locus tag | OY18_RS14000 | Protein ID | WP_010895221.1 |
| Coordinates | 20740..21225 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | Q9PHI1 |
| Locus tag | OY18_RS13995 | Protein ID | WP_010895220.1 |
| Coordinates | 20471..20743 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OY18_RS13960 (OY18_13150) | 17468..17665 | + | 198 | WP_042464033.1 | hypothetical protein | - |
| OY18_RS13965 (OY18_13155) | 17662..17988 | + | 327 | WP_010895215.1 | hypothetical protein | - |
| OY18_RS13975 (OY18_13165) | 18348..18905 | - | 558 | WP_042464084.1 | recombinase family protein | - |
| OY18_RS13980 (OY18_13170) | 18964..19266 | - | 303 | WP_010895217.1 | hypothetical protein | - |
| OY18_RS13985 (OY18_13175) | 19417..19836 | - | 420 | WP_010895219.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| OY18_RS13990 (OY18_13180) | 19836..20075 | - | 240 | WP_004085761.1 | ribbon-helix-helix domain-containing protein | - |
| OY18_RS13995 (OY18_13185) | 20471..20743 | + | 273 | WP_010895220.1 | DUF1778 domain-containing protein | Antitoxin |
| OY18_RS14000 (OY18_13190) | 20740..21225 | + | 486 | WP_010895221.1 | GNAT family N-acetyltransferase | Toxin |
| OY18_RS14005 (OY18_13195) | 21709..21972 | - | 264 | WP_088569753.1 | DUF4190 domain-containing protein | - |
| OY18_RS14010 (OY18_13200) | 22037..22363 | - | 327 | WP_010895223.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| OY18_RS14015 (OY18_13205) | 22350..22580 | - | 231 | WP_042464041.1 | hypothetical protein | - |
| OY18_RS14020 (OY18_13210) | 22860..23141 | - | 282 | WP_088569754.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS14025 (OY18_13215) | 23150..23317 | - | 168 | WP_042464043.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS14030 (OY18_13220) | 23305..23558 | - | 254 | Protein_29 | CopG family ribbon-helix-helix protein | - |
| OY18_RS14035 (OY18_13225) | 23818..24837 | - | 1020 | WP_010895227.1 | hypothetical protein | - |
| OY18_RS14040 (OY18_13230) | 25198..25954 | - | 757 | Protein_31 | alpha/beta hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..51180 | 51180 | |
| - | flank | IS/Tn | - | - | 18348..18905 | 557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17895.74 Da Isoelectric Point: 9.4154
>T49887 WP_010895221.1 NZ_CP009825:20740-21225 [Xylella fastidiosa]
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRCALTNHLNGASRTFVVVDANQYVLGYYALAAGSVAHQEATRAIRRNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQFIAENVGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F
VNMQISTPHSLTAAHRLDEFNCGEPSLDDWLKRCALTNHLNGASRTFVVVDANQYVLGYYALAAGSVAHQEATRAIRRNM
PDPVPVMVLGRLAVDTRAQGIKLGAALLKDTVTRVQFIAENVGVRALVVHALNERAKQFYEYYGFRASPMHLMTLMLPIK
F
Download Length: 486 bp
>T49887 NZ_CP009825:20740-21225 [Xylella fastidiosa]
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTCGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGATGCGCATTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTTGTTGTCGATGCCAACC
AGTACGTGCTTGGGTACTACGCTTTGGCAGCTGGGTCTGTCGCGCATCAAGAGGCCACGCGTGCTATCCGACGTAATATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTAGATACTCGCGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTACAGTTCATTGCAGAGAACGTCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG
GTGAATATGCAGATTTCGACACCTCATTCACTCACGGCAGCGCATCGACTCGATGAATTCAATTGCGGTGAGCCATCGCT
GGATGATTGGCTTAAACGATGCGCATTGACCAACCATTTAAACGGGGCCAGCCGGACCTTCGTTGTTGTCGATGCCAACC
AGTACGTGCTTGGGTACTACGCTTTGGCAGCTGGGTCTGTCGCGCATCAAGAGGCCACGCGTGCTATCCGACGTAATATG
CCTGATCCAGTGCCGGTCATGGTGCTCGGAAGGCTGGCTGTAGATACTCGCGCTCAAGGCATCAAACTCGGTGCGGCCTT
GCTTAAAGATACGGTAACTCGTGTACAGTTCATTGCAGAGAACGTCGGCGTCAGGGCATTGGTAGTCCATGCGTTGAACG
AGCGCGCAAAGCAATTCTACGAGTACTATGGTTTTCGAGCGTCACCAATGCACCTGATGACCTTGATGCTTCCGATTAAA
TTCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10237.74 Da Isoelectric Point: 4.7419
>AT49887 WP_010895220.1 NZ_CP009825:20471-20743 [Xylella fastidiosa]
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLDGPQDTNLGLNRLMA
IKAPWSIGNT
MRDASINLRAMPEQRDLIDQAANLLGKNRSDFMLEAACERAKAIILDQVFFNLDEERFRQFTVLLDGPQDTNLGLNRLMA
IKAPWSIGNT
Download Length: 273 bp
>AT49887 NZ_CP009825:20471-20743 [Xylella fastidiosa]
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTGATGGGCCACAAGACACCAATCTCGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCGGCAATACGTGA
ATGCGCGACGCTTCCATCAACTTACGTGCCATGCCTGAGCAGCGCGACTTGATTGACCAGGCTGCTAATCTATTAGGCAA
GAATCGCTCAGACTTCATGCTAGAAGCTGCGTGCGAGCGTGCGAAAGCAATTATCCTGGATCAAGTCTTTTTTAATCTGG
ACGAAGAGAGGTTCCGGCAATTCACTGTGTTGCTTGATGGGCCACAAGACACCAATCTCGGCCTTAATCGCCTGATGGCA
ATTAAGGCTCCGTGGAGCATCGGCAATACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|