Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2656..3139 Replicon plasmid pXF27-J1
Accession NZ_CP009824
Organism Xylella fastidiosa strain J1a12

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag OY18_RS13720 Protein ID WP_060871666.1
Coordinates 2870..3139 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag OY18_RS13715 Protein ID WP_060871665.1
Coordinates 2656..2886 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OY18_RS13695 (OY18_12900) 18..1121 - 1104 WP_081089762.1 replication protein RepA -
OY18_RS13700 (OY18_12905) 1148..1751 - 604 Protein_1 recombinase family protein -
OY18_RS13705 (OY18_12910) 1973..2203 + 231 WP_042464041.1 hypothetical protein -
OY18_RS13710 (OY18_12915) 2190..2516 + 327 WP_060872373.1 type II toxin-antitoxin system PemK/MazF family toxin -
OY18_RS13715 (OY18_12920) 2656..2886 + 231 WP_060871665.1 DUF6290 family protein Antitoxin
OY18_RS13720 (OY18_12925) 2870..3139 + 270 WP_060871666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OY18_RS13725 (OY18_12930) 3188..3469 - 282 WP_229926367.1 hypothetical protein -
OY18_RS15320 3438..3602 - 165 WP_229926368.1 hypothetical protein -
OY18_RS13735 (OY18_12940) 4453..4632 + 180 WP_081089764.1 hypothetical protein -
OY18_RS13740 (OY18_12945) 4720..5115 + 396 WP_229926369.1 hypothetical protein -
OY18_RS13745 (OY18_12950) 5118..5438 + 321 WP_060871671.1 TrbC/VirB2 family protein -
OY18_RS13750 (OY18_12955) 5443..5826 + 384 WP_013087959.1 VirB3 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..27268 27268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10295.89 Da        Isoelectric Point: 10.2721

>T49885 WP_060871666.1 NZ_CP009824:2870-3139 [Xylella fastidiosa]
MAWKVELSSLAQKNLDQLDPQIARRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR

Download         Length: 270 bp

>T49885 NZ_CP009824:2870-3139 [Xylella fastidiosa]
ATGGCATGGAAGGTTGAGCTTTCGTCGTTGGCTCAAAAAAACCTTGACCAGCTTGACCCACAAATTGCACGGCGTGTCTT
GTCCTTTCTGCATGAGCGCGTGGCCCCGCTGGACGATCCGCGCAGCATCGGTGAATCCCTCAAGGGTTCGCGCCTTGGTG
AGTTTTGGAAGTACCGCGTGGGTGATTACCGGATTATCAGCAGCATCGAGGACGGCGCTTTGCGCATCCTCGTTGTGAAG
ATCGGCAACCGCCGCGAGGTGTACCGCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8675.92 Da        Isoelectric Point: 4.3690

>AT49885 WP_060871665.1 NZ_CP009824:2656-2886 [Xylella fastidiosa]
MVSVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAECELEAIRSGKSQTVPLEEVMKRYGMEG

Download         Length: 231 bp

>AT49885 NZ_CP009824:2656-2886 [Xylella fastidiosa]
ATGGTTTCCGTATCACTGCGCCTGCCTGATGAAGTCACACAACGACTTGAGAACTTGGCCGCGCTCACAGGACGTAGCAA
GACCTTCTACATGGTGGAAGCCATCCGCGAACACATCGACGACCTGGAAGACTTGTATTTGGCCGAGTGTGAGCTTGAAG
CGATCCGTTCTGGCAAGTCGCAAACCGTACCACTCGAAGAAGTGATGAAACGCTATGGCATGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References