Detailed information of TA system TA049883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2766410..2767009
• Replicon: chromosome
• Accession: NZ_CP009823
• Organism: Xylella fastidiosa strain J1a12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OY18_RS13610
• Protein ID: WP_228762756.1
• Coordinates: 2766722..2767009 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9P9V8
• Locus tag: OY18_RS13605
• Protein ID: WP_010895177.1
• Coordinates: 2766410..2766718 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OY18_RS13565 (OY18_12730)	2762196..2762486	-	291	WP_088569732.1	hypothetical protein	-
OY18_RS13570 (OY18_12735)	2762986..2763747	-	762	WP_010895174.1	Bax inhibitor-1/YccA family protein	-
OY18_RS13600 (OY18_12765)	2764942..2766336	+	1395	WP_060871755.1	hypothetical protein	-
OY18_RS13605 (OY18_12770)	2766410..2766718	-	309	WP_010895177.1	putative addiction module antidote protein	Antitoxin
OY18_RS13610 (OY18_12775)	2766722..2767009	-	288	WP_228762756.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OY18_RS13615 (OY18_12780)	2767105..2767875	+	771	WP_088569733.1	hypothetical protein	-
OY18_RS13620 (OY18_12785)	2767875..2768141	+	267	WP_088569734.1	hypothetical protein	-
OY18_RS13625 (OY18_12790)	2768479..2768852	-	374	Protein_2526	DUF596 domain-containing protein	-
OY18_RS13630 (OY18_12795)	2768864..2770006	-	1143	WP_229926308.1	DUF769 domain-containing protein	-
OY18_RS13635 (OY18_12800)	2770401..2770778	-	378	WP_088569749.1	DUF596 domain-containing protein	-
OY18_RS13640 (OY18_12805)	2770790..2771134	-	345	Protein_2529	DUF769 domain-containing protein	-
OY18_RS13645 (OY18_12810)	2771294..2771686	-	393	WP_060872241.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2764942..2768141	3199

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10939.63 Da
• Isoelectric Point: 10.3074

>T49883 WP_228762756.1 NZ_CP009823:c2767009-2766722 [Xylella fastidiosa]
VKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDKSTQQ
SDIRRAIELAKSLED

Nucleotide

• Length: 288 bp

>T49883 NZ_CP009823:c2767009-2766722 [Xylella fastidiosa]
GTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCTCATCAAGCGCTT
ACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGCGCGAACACTTCGGAC
CTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAGTCAACGCAACAA
TCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11038.60 Da
• Isoelectric Point: 4.6561

>AT49883 WP_010895177.1 NZ_CP009823:c2766718-2766410 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Nucleotide

• Length: 309 bp

>AT49883 NZ_CP009823:c2766718-2766410 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V409