Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 2034102..2034664 | Replicon | chromosome |
| Accession | NZ_CP009823 | ||
| Organism | Xylella fastidiosa strain J1a12 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9PBR6 |
| Locus tag | OY18_RS10050 | Protein ID | WP_010894527.1 |
| Coordinates | 2034368..2034664 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9PBR5 |
| Locus tag | OY18_RS10045 | Protein ID | WP_010894528.1 |
| Coordinates | 2034102..2034380 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OY18_RS10015 (OY18_09465) | 2030198..2031004 | + | 807 | WP_010894535.1 | oxidoreductase | - |
| OY18_RS10020 (OY18_09470) | 2031334..2031594 | + | 261 | WP_010894534.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| OY18_RS10025 | 2031581..2031862 | + | 282 | WP_010894533.1 | type II toxin-antitoxin system YafQ family toxin | - |
| OY18_RS15130 (OY18_09480) | 2031915..2032169 | - | 255 | Protein_1872 | conjugal transfer protein TrbJ | - |
| OY18_RS10035 (OY18_09485) | 2032275..2033315 | - | 1041 | WP_060872291.1 | hypothetical protein | - |
| OY18_RS10045 (OY18_09495) | 2034102..2034380 | + | 279 | WP_010894528.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| OY18_RS10050 (OY18_09500) | 2034368..2034664 | + | 297 | WP_010894527.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OY18_RS10060 (OY18_09505) | 2035321..2035563 | + | 243 | WP_010894524.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| OY18_RS15135 | 2035556..2035741 | + | 186 | WP_229926279.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS15140 | 2036306..2036569 | + | 264 | WP_023906433.1 | hypothetical protein | - |
| OY18_RS15145 | 2036633..2036740 | + | 108 | WP_257000796.1 | hypothetical protein | - |
| OY18_RS10075 (OY18_09520) | 2037149..2037604 | + | 456 | WP_010894521.1 | hypothetical protein | - |
| OY18_RS10080 (OY18_09525) | 2037601..2037873 | + | 273 | WP_010894520.1 | hypothetical protein | - |
| OY18_RS10085 (OY18_09530) | 2037877..2038185 | + | 309 | WP_010894519.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OY18_RS10090 (OY18_09535) | 2038294..2038563 | + | 270 | WP_010894518.1 | hypothetical protein | - |
| OY18_RS10095 (OY18_09540) | 2038615..2038818 | + | 204 | WP_023906434.1 | hypothetical protein | - |
| OY18_RS10100 (OY18_09545) | 2038812..2039347 | + | 536 | Protein_1885 | recombinase family protein | - |
| OY18_RS10105 (OY18_09550) | 2039377..2039586 | - | 210 | WP_010894516.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pilG | 2016575..2250627 | 234052 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11155.72 Da Isoelectric Point: 7.4670
>T49881 WP_010894527.1 NZ_CP009823:2034368-2034664 [Xylella fastidiosa]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS
Download Length: 297 bp
>T49881 NZ_CP009823:2034368-2034664 [Xylella fastidiosa]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10772.08 Da Isoelectric Point: 5.6126
>AT49881 WP_010894528.1 NZ_CP009823:2034102-2034380 [Xylella fastidiosa]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG
Download Length: 279 bp
>AT49881 NZ_CP009823:2034102-2034380 [Xylella fastidiosa]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0VAK4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1S0V821 |