Detailed information of TA system TA049880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 2031334..2031862
• Replicon: chromosome
• Accession: NZ_CP009823
• Organism: Xylella fastidiosa strain J1a12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OY18_RS10025
• Protein ID: WP_010894533.1
• Coordinates: 2031581..2031862 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q9PBQ9
• Locus tag: OY18_RS10020
• Protein ID: WP_010894534.1
• Coordinates: 2031334..2031594 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OY18_RS10010 (OY18_09460)	2027090..2030152	+	3063	WP_060872292.1	efflux RND transporter permease subunit	-
OY18_RS10015 (OY18_09465)	2030198..2031004	+	807	WP_010894535.1	oxidoreductase	-
OY18_RS10020 (OY18_09470)	2031334..2031594	+	261	WP_010894534.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OY18_RS10025	2031581..2031862	+	282	WP_010894533.1	type II toxin-antitoxin system YafQ family toxin	Toxin
OY18_RS15130 (OY18_09480)	2031915..2032169	-	255	Protein_1872	conjugal transfer protein TrbJ	-
OY18_RS10035 (OY18_09485)	2032275..2033315	-	1041	WP_060872291.1	hypothetical protein	-
OY18_RS10045 (OY18_09495)	2034102..2034380	+	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
OY18_RS10050 (OY18_09500)	2034368..2034664	+	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
OY18_RS10060 (OY18_09505)	2035321..2035563	+	243	WP_010894524.1	type II toxin-antitoxin system ParD family antitoxin	-
OY18_RS15135	2035556..2035741	+	186	WP_229926279.1	type II toxin-antitoxin system RelE/ParE family toxin	-
OY18_RS15140	2036306..2036569	+	264	WP_023906433.1	hypothetical protein	-
OY18_RS15145	2036633..2036740	+	108	WP_257000796.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pilG	2016575..2250627	234052

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10727.49 Da
• Isoelectric Point: 9.0869

>T49880 WP_010894533.1 NZ_CP009823:2031581-2031862 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALLGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T49880 NZ_CP009823:2031581-2031862 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGCTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8997.58 Da
• Isoelectric Point: 10.5972

>AT49880 WP_010894534.1 NZ_CP009823:2031334-2031594 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTISDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT49880 NZ_CP009823:2031334-2031594 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCATTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: Q9PBQ9