Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 917008..917804 | Replicon | chromosome |
| Accession | NZ_CP009823 | ||
| Organism | Xylella fastidiosa strain J1a12 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | - |
| Locus tag | OY18_RS04550 | Protein ID | WP_023907999.1 |
| Coordinates | 917193..917804 (+) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | A0A060HF63 |
| Locus tag | OY18_RS04545 | Protein ID | WP_004087046.1 |
| Coordinates | 917008..917196 (+) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OY18_RS04500 (OY18_04215) | 912616..913542 | - | 927 | WP_060871932.1 | phage recombination protein Bet | - |
| OY18_RS04505 (OY18_04220) | 913558..914379 | - | 822 | WP_060871933.1 | YfdQ family protein | - |
| OY18_RS04510 (OY18_04225) | 914419..914763 | - | 345 | WP_023906563.1 | hypothetical protein | - |
| OY18_RS04515 (OY18_04230) | 914784..914975 | - | 192 | WP_023906562.1 | hypothetical protein | - |
| OY18_RS04520 (OY18_04235) | 914999..915190 | - | 192 | WP_004086365.1 | hypothetical protein | - |
| OY18_RS04525 (OY18_04240) | 915187..915588 | - | 402 | WP_060871934.1 | hypothetical protein | - |
| OY18_RS04530 (OY18_04245) | 915585..916067 | - | 483 | WP_060871935.1 | hypothetical protein | - |
| OY18_RS04535 (OY18_04250) | 916064..916606 | - | 543 | WP_081089799.1 | hypothetical protein | - |
| OY18_RS04545 (OY18_04255) | 917008..917196 | + | 189 | WP_004087046.1 | antitoxin VbhA family protein | Antitoxin |
| OY18_RS04550 (OY18_04260) | 917193..917804 | + | 612 | WP_023907999.1 | Fic/DOC family protein | Toxin |
| OY18_RS04555 (OY18_04265) | 917855..918634 | - | 780 | WP_023907998.1 | helix-turn-helix transcriptional regulator | - |
| OY18_RS04560 (OY18_04270) | 918633..918878 | + | 246 | WP_023907997.1 | hypothetical protein | - |
| OY18_RS04565 (OY18_04275) | 918875..919180 | - | 306 | WP_060871936.1 | hypothetical protein | - |
| OY18_RS04570 (OY18_04280) | 919282..919563 | + | 282 | WP_023907994.1 | hypothetical protein | - |
| OY18_RS04575 (OY18_04285) | 919624..919812 | + | 189 | WP_042463208.1 | hypothetical protein | - |
| OY18_RS04580 (OY18_04290) | 919842..920057 | + | 216 | WP_229926343.1 | hypothetical protein | - |
| OY18_RS04585 (OY18_04295) | 920054..920419 | + | 366 | WP_060871938.1 | hypothetical protein | - |
| OY18_RS14930 (OY18_04300) | 920737..920970 | + | 234 | Protein_842 | Bro-N domain-containing protein | - |
| OY18_RS04595 (OY18_04305) | 921307..921942 | + | 636 | WP_060871944.1 | Bro-N domain-containing protein | - |
| OY18_RS04600 (OY18_04310) | 921939..922730 | + | 792 | WP_060871939.1 | Bro-N domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 790250..953208 | 162958 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22919.68 Da Isoelectric Point: 4.9434
>T49878 WP_023907999.1 NZ_CP009823:917193-917804 [Xylella fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKEQFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIRDGISDQLFKDNE
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKEQFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIRDGISDQLFKDNE
Download Length: 612 bp
>T49878 NZ_CP009823:917193-917804 [Xylella fastidiosa]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGCCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCAATTTTTGTGTGGCCTTGATGCTGAGGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACAGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGCGGATTGGC
TAGTATCATCCGCGATGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGCCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCAATTTTTGTGTGGCCTTGATGCTGAGGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACAGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGCGGATTGGC
TAGTATCATCCGCGATGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6855.80 Da Isoelectric Point: 4.9859
>AT49878 WP_004087046.1 NZ_CP009823:917008-917196 [Xylella fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA
Download Length: 189 bp
>AT49878 NZ_CP009823:917008-917196 [Xylella fastidiosa]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|