Detailed information of TA system TA049874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 855992..856478
• Replicon: chromosome
• Accession: NZ_CP009823
• Organism: Xylella fastidiosa strain J1a12

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: OY18_RS04100
• Protein ID: WP_060871810.1
• Coordinates: 855992..856267 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1L2AR28
• Locus tag: OY18_RS04105
• Protein ID: WP_031336679.1
• Coordinates: 856251..856478 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OY18_RS04070 (OY18_03805)	852146..852583	+	438	WP_010894081.1	DUF3277 family protein	-
OY18_RS04075 (OY18_03810)	852580..853002	+	423	WP_060872210.1	putative phage tail assembly chaperone	-
OY18_RS04080 (OY18_03815)	853150..855039	+	1890	WP_060872211.1	hypothetical protein	-
OY18_RS04085	855366..855542	+	177	WP_088569668.1	Blp family class II bacteriocin	-
OY18_RS04090	855576..855764	+	189	WP_081089780.1	hypothetical protein	-
OY18_RS04095	855769..855939	-	171	WP_081089781.1	antitoxin	-
OY18_RS04100 (OY18_03825)	855992..856267	-	276	WP_060871810.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OY18_RS04105 (OY18_03830)	856251..856478	-	228	WP_031336679.1	DUF6290 family protein	Antitoxin
OY18_RS04110 (OY18_03835)	856591..857361	+	771	WP_088569669.1	hypothetical protein	-
OY18_RS04115 (OY18_03840)	857361..857678	+	318	WP_069107095.1	hypothetical protein	-
OY18_RS04120 (OY18_03845)	857675..858505	+	831	WP_060872216.1	hypothetical protein	-
OY18_RS04125 (OY18_03850)	858502..859323	+	822	WP_229926333.1	Gp138 family membrane-puncturing spike protein	-
OY18_RS14910	859307..859492	+	186	WP_229926334.1	hypothetical protein	-
OY18_RS04135 (OY18_03860)	859503..859808	-	306	WP_060872107.1	putative addiction module antidote protein	-
OY18_RS04140 (OY18_03865)	859805..860107	-	303	WP_060872108.1	type II toxin-antitoxin system RelE/ParE family toxin	-
OY18_RS04145 (OY18_03870)	860206..861351	+	1146	WP_060872109.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	790250..953208	162958

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10552.23 Da
• Isoelectric Point: 10.3419

>T49874 WP_060871810.1 NZ_CP009823:c856267-855992 [Xylella fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYRREC

Nucleotide

• Length: 276 bp

>T49874 NZ_CP009823:c856267-855992 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTGGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGACGAGAATGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8691.73 Da
• Isoelectric Point: 5.0958

>AT49874 WP_031336679.1 NZ_CP009823:c856478-856251 [Xylella fastidiosa]
MATSIRLSPEMEQRLNYLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT49874 NZ_CP009823:c856478-856251 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTATCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGAAAAACGCTTGGCCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L2AR28