Detailed information of TA system TA049863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 4511974..4512964
• Replicon: chromosome
• Accession: NZ_CP009801
• Organism: Yersinia intermedia strain Y228

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9M4G2
• Locus tag: CH53_RS20010
• Protein ID: WP_005184404.1
• Coordinates: 4512506..4512964 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9M4Z0
• Locus tag: CH53_RS20005
• Protein ID: WP_005184401.1
• Coordinates: 4511974..4512420 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH53_RS19985	4507634..4508341	+	708	WP_032906074.1	murein tripeptide amidase MpaA	-
CH53_RS19990	4508338..4509309	-	972	WP_042569804.1	L-Ala-D/L-Glu epimerase	-
CH53_RS19995	4509463..4509966	+	504	WP_005184397.1	thiol peroxidase	-
CH53_RS20000	4510079..4511656	-	1578	WP_042569805.1	transcriptional regulator TyrR	-
CH53_RS20005	4511974..4512420	+	447	WP_005184401.1	DUF2384 domain-containing protein	Antitoxin
CH53_RS20010	4512506..4512964	+	459	WP_005184404.1	RES family NAD+ phosphorylase	Toxin
CH53_RS20015	4512990..4514051	-	1062	WP_042569806.1	YcjF family protein	-
CH53_RS20020	4514048..4515445	-	1398	WP_032906079.1	YcjX family protein	-
CH53_RS20025	4515426..4515665	-	240	WP_005184410.1	phage shock protein PspD	-
CH53_RS20030	4515774..4516148	-	375	WP_005184415.1	envelope stress response membrane protein PspC	-
CH53_RS20035	4516148..4516375	-	228	WP_032906081.1	envelope stress response membrane protein PspB	-
CH53_RS20040	4516519..4517184	-	666	WP_005184417.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17201.65 Da
• Isoelectric Point: 4.8938

>T49863 WP_005184404.1 NZ_CP009801:4512506-4512964 [Yersinia intermedia]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALSFAFDPRLK

Nucleotide

• Length: 459 bp

>T49863 NZ_CP009801:4512506-4512964 [Yersinia intermedia]
ATGATGCTTTATCGCATCGTGATGCGCCGCTACCTGGCTTCAACCTGGACCGGTTATGGCGCTGAAATCTATGGTGGGCG
CTGGAATCATAAAGGCCACGCCGCCATCTATTTAGCCAGTAGTGTGTCACTGGCGATGCTGGAAACACTGGTACATATTC
AAGACAGCTCAACACTCAGCGAGTTTGAGTTATTCCAGATTGAGATTGATGACAGCAATATCATGCTGTTACAACCACAG
GATTGGCCACTGGACTGGCGCAATGACCCCGCGCCTGCGGCTACGATGGATATCGGCACAGAATGGCTGGAATCAGAATC
ATCAATTGGATTGCTGGTCCCATCCACACTGGTGCCTTCAGAACATAATATGCTGGTCAATCCGCGCCACAAAGATTTTC
AGGCCTGCTTGAGTACCGCCAAAGCACTCTCCTTTGCCTTCGATCCCCGATTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16256.70 Da
• Isoelectric Point: 9.1234

>AT49863 WP_005184401.1 NZ_CP009801:4511974-4512420 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT49863 NZ_CP009801:4511974-4512420 [Yersinia intermedia]
ATGAGAGCTTATCAACCTACCCCCACAACGAAAGCAGGGGCACTCTGGCGAGAAATTGGTTTACCAGCCAGCCGTGGCAC
GGTATTAGTCGACAGCATCAAGCTGGGTTTTTCTGTCGATGTCATCGACAGTATCCATCTTTGGGCCTCTATGCCTAAAT
CTGAAATATTGCGCGCTACCGGTATTCCCAGCCGTAGCCTGACCCGCCGACGTACCCATGATGGCCGTTTTACACCAGAA
GAGAGTGAGCGAATCGCGCGCTTCGTGCGGGTAATGGATGCCGCAGTTGACCTCTTCGGTGGTGATAAAGGCAAAGCTAT
CGTCTGGATGTCGACACCCATTAAGGGGCTTGGGCACCGCAGTCCTGACTCACTGCTGGAGACAGAAACCGGCGCGTTAG
AAATCTGCGATTTAATTGGGCGGCTGGAACACGGTGTATTTTCATAG

Structures

Toxin

• AlphaFold DB: A0A0T9M4G2

Antitoxin

• AlphaFold DB: A0A0T9M4Z0