Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3348967..3349670 Replicon chromosome
Accession NZ_CP009801
Organism Yersinia intermedia strain Y228

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CH53_RS14705 Protein ID WP_042569336.1
Coordinates 3348967..3349332 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CH53_RS14710 Protein ID WP_042569337.1
Coordinates 3349338..3349670 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH53_RS14670 3344296..3345213 + 918 WP_042569332.1 alpha/beta hydrolase -
CH53_RS14675 3346270..3346635 - 366 WP_052491287.1 porin family protein -
CH53_RS14680 3346671..3347102 + 432 WP_080774703.1 hypothetical protein -
CH53_RS14685 3347255..3347515 + 261 WP_042569334.1 hypothetical protein -
CH53_RS14690 3347648..3348079 + 432 WP_042569335.1 antirestriction protein -
CH53_RS14695 3348112..3348585 + 474 WP_042570110.1 DNA repair protein RadC -
CH53_RS14700 3348579..3348911 + 333 WP_052491288.1 hypothetical protein -
CH53_RS14705 3348967..3349332 + 366 WP_042569336.1 TA system toxin CbtA family protein Toxin
CH53_RS14710 3349338..3349670 + 333 WP_042569337.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CH53_RS14715 3349755..3350606 + 852 WP_042569338.1 DUF4942 domain-containing protein -
CH53_RS14725 3350762..3351450 - 689 Protein_2888 hypothetical protein -
CH53_RS22530 3351485..3351712 + 228 Protein_2889 transposase -
CH53_RS14735 3351792..3354080 + 2289 WP_042569341.1 heavy metal translocating P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13461.41 Da        Isoelectric Point: 6.7230

>T49861 WP_042569336.1 NZ_CP009801:3348967-3349332 [Yersinia intermedia]
MKPRPTPPGALPVSAIYQQLLAFLLENHYGLSLNDTPYHDEQVIAQQIEQEISVGDTVNTLVEKYALVRIGRTGFSALAQ
DPMLSKGDIVRARQAAGLWRAHFPPTLLYPTESLNPIQPQR

Download         Length: 366 bp

>T49861 NZ_CP009801:3348967-3349332 [Yersinia intermedia]
ATGAAACCACGACCCACCCCACCGGGCGCATTGCCCGTGTCTGCGATTTATCAACAACTGCTCGCTTTCCTGCTGGAGAA
TCACTACGGCCTGAGCCTCAACGATACGCCTTATCACGATGAACAGGTGATTGCACAACAGATAGAACAAGAGATTTCCG
TTGGTGACACCGTCAATACCCTGGTTGAGAAATATGCCTTAGTGCGTATTGGTCGTACCGGGTTCAGTGCATTGGCACAA
GACCCGATGTTGAGCAAAGGTGATATCGTGCGGGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCAACCACAGAGATAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12174.74 Da        Isoelectric Point: 6.4836

>AT49861 WP_042569337.1 NZ_CP009801:3349338-3349670 [Yersinia intermedia]
MDNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQTLDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGEFVCEADTLGSHGYVYISVYQELS

Download         Length: 333 bp

>AT49861 NZ_CP009801:3349338-3349670 [Yersinia intermedia]
ATGGATAACCACATTACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGACTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAGTTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTATGTCTATATCTCGGTGTATCA
GGAGCTGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References