Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2667706..2668172 Replicon chromosome
Accession NZ_CP009801
Organism Yersinia intermedia strain Y228

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9MGJ2
Locus tag CH53_RS11680 Protein ID WP_032906934.1
Coordinates 2667706..2667981 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9MGP0
Locus tag CH53_RS11685 Protein ID WP_032906933.1
Coordinates 2667981..2668172 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH53_RS11665 2662730..2664997 + 2268 WP_042569053.1 DNA topoisomerase IV subunit A -
CH53_RS11670 2665220..2665960 + 741 WP_042569054.1 1-acylglycerol-3-phosphate O-acyltransferase -
CH53_RS11675 2666132..2667559 + 1428 WP_005188253.1 cell division protein FtsP -
CH53_RS11680 2667706..2667981 - 276 WP_032906934.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CH53_RS11685 2667981..2668172 - 192 WP_032906933.1 hypothetical protein Antitoxin
CH53_RS11690 2668343..2670613 + 2271 WP_042569055.1 YgiQ family radical SAM protein -
CH53_RS11695 2670635..2671468 - 834 WP_005188245.1 2,5-didehydrogluconate reductase DkgA -
CH53_RS11700 2671785..2672942 - 1158 WP_005188243.1 alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10442.91 Da        Isoelectric Point: 4.7385

>T49858 WP_032906934.1 NZ_CP009801:c2667981-2667706 [Yersinia intermedia]
MLPIKWTDEAKTDLYALIAFITEENPYAAESLLHQLEDSVLPATEHPYMFRSGRVPGTREIVAHPNYVIIYQVMADQISV
LNVVHSRQEYP

Download         Length: 276 bp

>T49858 NZ_CP009801:c2667981-2667706 [Yersinia intermedia]
ATGCTCCCTATAAAATGGACTGACGAAGCAAAGACGGATCTTTATGCACTAATCGCGTTCATCACAGAAGAAAACCCTTA
CGCAGCAGAATCACTACTTCACCAACTGGAAGACTCCGTTCTTCCTGCTACTGAGCATCCCTATATGTTTCGCTCAGGTA
GAGTTCCTGGAACTCGAGAAATTGTGGCGCATCCCAATTACGTTATTATTTATCAGGTGATGGCTGACCAAATCAGCGTG
TTAAACGTTGTTCACTCTCGACAGGAATACCCGTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7164.16 Da        Isoelectric Point: 7.0117

>AT49858 WP_032906933.1 NZ_CP009801:c2668172-2667981 [Yersinia intermedia]
MSTKLSPIVSEFETEEQAESYDLWFRAKVEASMNSPKPQTPHDEVMAGARKIIEQAKARRKLA

Download         Length: 192 bp

>AT49858 NZ_CP009801:c2668172-2667981 [Yersinia intermedia]
ATGAGCACTAAATTATCACCAATCGTCTCTGAATTTGAAACCGAAGAACAGGCGGAAAGCTACGATCTTTGGTTCCGGGC
TAAGGTCGAGGCATCAATGAATAGCCCCAAACCCCAAACTCCTCACGATGAAGTCATGGCGGGTGCGCGCAAAATTATTG
AACAAGCCAAAGCACGGAGGAAGCTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MGJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9MGP0

References