Detailed information of TA system TA049854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1701719..1702254
• Replicon: chromosome
• Accession: NZ_CP009801
• Organism: Yersinia intermedia strain Y228

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: CH53_RS07560
• Protein ID: WP_042568753.1
• Coordinates: 1701946..1702254 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: CH53_RS07555
• Protein ID: WP_042568752.1
• Coordinates: 1701719..1701943 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH53_RS07540	1697386..1699518	+	2133	WP_042568750.1	FUSC family protein	-
CH53_RS07545	1699552..1700769	-	1218	WP_005186181.1	aspartate aminotransferase family protein	-
CH53_RS07550	1701027..1701602	-	576	WP_042568751.1	aminodeoxychorismate synthase component II	-
CH53_RS07555	1701719..1701943	+	225	WP_042568752.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
CH53_RS07560	1701946..1702254	+	309	WP_042568753.1	CcdB family protein	Toxin
CH53_RS07565	1702268..1703791	-	1524	WP_042568754.1	DUF853 family protein	-
CH53_RS07570	1703987..1704556	-	570	WP_005186177.1	peptidylprolyl isomerase A	-
CH53_RS07580	1704909..1706222	+	1314	WP_042570055.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (4-74)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11440.32 Da
• Isoelectric Point: 6.9455

>T49854 WP_042568753.1 NZ_CP009801:1701946-1702254 [Yersinia intermedia]
MQFTIYNNLGNSSNYPYLVDVQSDLIDVLTTRLVIPLFPISKIRTPPPERLCPVIVVTGERFVVMTHEMASIRCNLLGKI
AGNASSDRDRIKNAIDFLIDGF

Nucleotide

• Length: 309 bp

>T49854 NZ_CP009801:1701946-1702254 [Yersinia intermedia]
ATGCAATTCACTATTTATAATAATTTAGGCAATAGCAGTAATTACCCTTACCTCGTTGATGTACAAAGTGATCTTATTGA
TGTACTCACCACACGGCTCGTTATCCCATTATTTCCGATAAGCAAAATTCGCACACCACCGCCAGAGCGATTGTGCCCGG
TGATTGTTGTTACCGGTGAGAGATTTGTTGTAATGACTCACGAGATGGCCAGTATCCGATGTAACCTGCTTGGCAAGATT
GCAGGTAATGCATCATCGGATAGGGATCGTATAAAAAACGCTATTGATTTTTTAATTGATGGCTTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8373.65 Da
• Isoelectric Point: 6.4568

>AT49854 WP_042568752.1 NZ_CP009801:1701719-1701943 [Yersinia intermedia]
MATKRSVNVTLDPVLYEKAKLAGLNLSQLLAEKVKSCIHDIEMAKWRAENIAGLTELNRITEEHGLLSDDYRTF

Nucleotide

• Length: 225 bp

>AT49854 NZ_CP009801:1701719-1701943 [Yersinia intermedia]
ATGGCTACAAAACGTTCGGTTAATGTAACGCTTGATCCTGTATTGTACGAAAAGGCCAAACTGGCAGGGCTAAACTTATC
CCAATTATTGGCTGAAAAAGTGAAAAGCTGCATTCATGATATCGAAATGGCGAAATGGCGCGCAGAGAACATAGCGGGCC
TGACAGAACTCAACCGGATTACAGAAGAACACGGATTACTTTCTGATGATTACAGGACGTTCTGA