Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 641606..642141 Replicon chromosome
Accession NZ_CP009801
Organism Yersinia intermedia strain Y228

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9M850
Locus tag CH53_RS02760 Protein ID WP_042568392.1
Coordinates 641606..641893 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9M846
Locus tag CH53_RS02765 Protein ID WP_032905973.1
Coordinates 641890..642141 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH53_RS02735 636918..637844 + 927 WP_005183819.1 oxygen-dependent coproporphyrinogen oxidase -
CH53_RS02740 637844..638299 + 456 WP_032905970.1 YaiI/YqxD family protein -
CH53_RS02745 638386..640665 - 2280 WP_005183822.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
CH53_RS02755 641001..641576 - 576 WP_042570012.1 GDP-mannose pyrophosphatase NudK -
CH53_RS02760 641606..641893 - 288 WP_042568392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH53_RS02765 641890..642141 - 252 WP_032905973.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CH53_RS02770 642272..642871 - 600 WP_042568393.1 cytochrome c-type protein NapC -
CH53_RS02775 642900..643367 - 468 WP_042568394.1 nitrate reductase cytochrome c-type subunit -
CH53_RS02780 643463..645958 - 2496 WP_032905975.1 nitrate reductase catalytic subunit NapA -
CH53_RS02785 645955..646221 - 267 WP_032905977.1 chaperone NapD -
CH53_RS02790 646211..646714 - 504 WP_042568395.1 ferredoxin-type protein NapF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.03 Da        Isoelectric Point: 10.3510

>T49853 WP_042568392.1 NZ_CP009801:c641893-641606 [Yersinia intermedia]
MTYAVKFREEALKEWHKLDKTIQQQFAKKLKKCSDNPHIESAKLRGMKNCYKIKLRSSGFRLVYEVIDDVLIVAVVAVGK
RDRSEVYNLASDRLR

Download         Length: 288 bp

>T49853 NZ_CP009801:c641893-641606 [Yersinia intermedia]
ATGACCTATGCCGTTAAGTTCAGAGAAGAAGCGCTAAAGGAATGGCACAAACTGGATAAGACGATACAACAGCAATTTGC
CAAGAAATTAAAAAAGTGCAGCGATAATCCGCATATTGAAAGCGCTAAACTACGTGGTATGAAAAACTGCTACAAAATTA
AATTACGATCCTCTGGATTTCGATTAGTGTATGAAGTTATCGATGATGTGTTGATCGTTGCTGTGGTTGCAGTAGGAAAA
AGAGATCGTAGCGAGGTGTATAACCTTGCAAGTGACCGATTACGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9255.56 Da        Isoelectric Point: 4.3287

>AT49853 WP_032905973.1 NZ_CP009801:c642141-641890 [Yersinia intermedia]
MPSIILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPAFYCVPAELYEQIMEALDDHELAELVNRRRHQPLLDIDLD
SYL

Download         Length: 252 bp

>AT49853 NZ_CP009801:c642141-641890 [Yersinia intermedia]
ATGCCAAGTATAATTTTGACTGATACCAGTGCCAGCGTGAGCGAACTGAAAAAAAATCCAATGGCAACAGTGAACGCTGG
GGCCGGTTTCCCCGTAGCTATCCTGAACCGCAATCAACCCGCATTCTATTGTGTACCCGCAGAACTGTATGAACAAATAA
TGGAAGCGCTTGATGATCACGAATTAGCTGAGTTGGTTAACAGGCGGCGCCATCAACCCTTGCTTGATATCGATTTGGAT
AGCTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M850

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M846

References