Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2558784..2559425 Replicon chromosome
Accession NZ_CP009799
Organism Burkholderia ambifaria AMMD

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CH72_RS27630 Protein ID WP_041491610.1
Coordinates 2559087..2559425 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CH72_RS27625 Protein ID WP_006750245.1
Coordinates 2558784..2559083 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH72_RS27600 2553930..2555219 + 1290 WP_041491608.1 Rieske 2Fe-2S domain-containing protein -
CH72_RS27605 2555216..2555704 + 489 WP_011660415.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
CH72_RS27610 2555722..2556048 + 327 WP_006756593.1 non-heme iron oxygenase ferredoxin subunit -
CH72_RS27615 2556038..2557258 + 1221 WP_011660416.1 FAD-dependent oxidoreductase -
CH72_RS27620 2557446..2558732 + 1287 WP_041491609.1 DUF445 domain-containing protein -
CH72_RS27625 2558784..2559083 - 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
CH72_RS27630 2559087..2559425 - 339 WP_041491610.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH72_RS27635 2559729..2561369 + 1641 WP_011660419.1 acetolactate synthase large subunit -
CH72_RS27640 2561398..2562831 + 1434 WP_011660420.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-109)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12599.61 Da        Isoelectric Point: 10.2348

>T49851 WP_041491610.1 NZ_CP009799:c2559425-2559087 [Burkholderia ambifaria AMMD]
MVDMLPFMPYSAPAFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRVDHGPGYRVYYVRRG
TIWVILLCGGDKSTQRAGIRAAHAMLARLDLE

Download         Length: 339 bp

>T49851 NZ_CP009799:c2559425-2559087 [Burkholderia ambifaria AMMD]
ATGGTTGACATGCTGCCATTCATGCCATACAGTGCACCTGCATTCAGTATCCGGACCACCGACGTCTTCGACGCGTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGGCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCTCCCGTCGTCGAAATGCGTGTCGATCACGGGCCCGGCTATCGCGTCTACTACGTCAGGCGCGGA
ACGATATGGGTGATCCTGCTCTGCGGCGGCGACAAGTCGACGCAACGGGCGGGCATCCGCGCCGCGCACGCGATGCTCGC
GCGGCTCGACCTGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT49851 WP_006750245.1 NZ_CP009799:c2559083-2558784 [Burkholderia ambifaria AMMD]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT49851 NZ_CP009799:c2559083-2558784 [Burkholderia ambifaria AMMD]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGACTATTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAGGCGCACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References