Detailed information of TA system TA049850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1817886..1818405
• Replicon: chromosome
• Accession: NZ_CP009799
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q0B638
• Locus tag: CH72_RS24365
• Protein ID: WP_011659780.1
• Coordinates: 1817886..1818167 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0B637
• Locus tag: CH72_RS24370
• Protein ID: WP_011659781.1
• Coordinates: 1818157..1818405 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH72_RS24345	1813542..1814240	-	699	WP_011659777.1	MgtC/SapB family protein	-
CH72_RS24350	1814352..1815461	+	1110	WP_041491549.1	AGE family epimerase/isomerase	-
CH72_RS24355	1815434..1817059	-	1626	WP_011659779.1	Tar ligand binding domain-containing protein	-
CH72_RS24360	1817320..1817763	+	444	WP_006757720.1	PaaI family thioesterase	-
CH72_RS24365	1817886..1818167	-	282	WP_011659780.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH72_RS24370	1818157..1818405	-	249	WP_011659781.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CH72_RS24375	1818548..1819600	-	1053	WP_011659782.1	CoA transferase	-
CH72_RS24380	1819959..1821149	-	1191	WP_011659783.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10930.84 Da
• Isoelectric Point: 10.3961

>T49850 WP_011659780.1 NZ_CP009799:c1818167-1817886 [Burkholderia ambifaria AMMD]
MTFELAFLEPALKEWKKLDRTICDQFKSRLAERLENPRIASAKLHGHPDRYKIKLRSVGYRLVYEVRDTEVIVLVVAVGR
RDRDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T49850 NZ_CP009799:c1818167-1817886 [Burkholderia ambifaria AMMD]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCATCTGCGACCAGTTCAA
ATCCCGACTCGCCGAGCGCCTCGAGAATCCCCGCATTGCGTCGGCCAAGCTGCATGGCCATCCGGATCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTACCGACTCGTCTACGAAGTGCGCGATACGGAAGTGATCGTACTGGTTGTCGCAGTCGGTCGC
CGTGACCGCGATGCCGTCTATCTTGCCGCGATGAAGCGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8989.36 Da
• Isoelectric Point: 5.6566

>AT49850 WP_011659781.1 NZ_CP009799:c1818405-1818157 [Burkholderia ambifaria AMMD]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALANTRAKDKVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT49850 NZ_CP009799:c1818405-1818157 [Burkholderia ambifaria AMMD]
ATGCCTCACACCATTCTGGCCAATGTTACGGCGAGCGTTTCGGAACTGAAGCGCAATCCGATGGGAACCGTCGCGGCGGG
CGAGGGCTTTCCGGTTGCGATTCTGAATCACAACGAGCCCGCGTTCTATTGCATCCCGGCGAAGACGTGGGAAGCGATGG
TCGAACGTCTCGAAGATATAGAAGACAACGCGCTTGCCAATACGCGTGCGAAGGACAAGGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Toxin

• AlphaFold DB: Q0B638

Antitoxin

• AlphaFold DB: Q0B637