Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1006989..1008754 Replicon chromosome
Accession NZ_CP009799
Organism Burkholderia ambifaria AMMD

Toxin (Protein)


Gene name doc Uniprot ID Q0B870
Locus tag CH72_RS20725 Protein ID WP_011659095.1
Coordinates 1007843..1008754 (-) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q0B871
Locus tag CH72_RS20720 Protein ID WP_011659094.1
Coordinates 1006989..1007846 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH72_RS20700 1002126..1003616 - 1491 WP_011659090.1 aldehyde dehydrogenase -
CH72_RS20705 1003715..1004542 - 828 WP_011659091.1 aspartate dehydrogenase -
CH72_RS20710 1004535..1006202 - 1668 WP_011659092.1 thiamine pyrophosphate-binding protein -
CH72_RS20715 1006195..1006992 - 798 WP_011659093.1 SDR family oxidoreductase -
CH72_RS20720 1006989..1007846 - 858 WP_011659094.1 IclR family transcriptional regulator Antitoxin
CH72_RS20725 1007843..1008754 - 912 WP_011659095.1 alpha/beta fold hydrolase Toxin
CH72_RS20730 1008774..1009301 - 528 WP_006751280.1 cupin domain-containing protein -
CH72_RS20735 1009341..1010111 - 771 WP_011659096.1 SDR family oxidoreductase -
CH72_RS20740 1010104..1011174 - 1071 WP_011659097.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CH72_RS20745 1011229..1011540 - 312 WP_011659098.1 hypothetical protein -
CH72_RS20750 1011542..1011859 - 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
CH72_RS20755 1012310..1013389 + 1080 WP_011659099.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, C-terminal

(144-266)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31306.55 Da        Isoelectric Point: 6.5933

>T49847 WP_011659095.1 NZ_CP009799:c1008754-1007843 [Burkholderia ambifaria AMMD]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHDASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLAMLDELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA

Download         Length: 912 bp

>T49847 NZ_CP009799:c1008754-1007843 [Burkholderia ambifaria AMMD]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTTGCGTGGGATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGACGCGTCGCCGACCGCCGCCGATTACGC
GGCGTCGCTGAATGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGCGGCCTGTGCCGCCTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGTGCG
CCCGCCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGATGCTCGACGAACTCGGTCCGGCCGGGCTCGCCGAGCA
GCGCAGTGGCAACATGCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTCCGCGGCCGCACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAATT
GCAGGTGATTCCGCAGGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCGTCGCTTATCGACACGTTCTGTC
GTCAGTGCGACACGCAGCGAGGCATGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31403.94 Da        Isoelectric Point: 6.3573

>AT49847 WP_011659094.1 NZ_CP009799:c1007846-1006989 [Burkholderia ambifaria AMMD]
MSEPLQQPESDSTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT49847 NZ_CP009799:c1007846-1006989 [Burkholderia ambifaria AMMD]
ATGAGCGAACCGCTGCAACAACCAGAATCCGACAGCACCAAGGCCGACGCCGGCTACGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGTGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCGGACAAGGATCGCAACTACAAG
CTGGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGTGTTCAGCGCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAATGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q0B870

Antitoxin

Source ID Structure
AlphaFold DB Q0B871

References