Detailed information of TA system TA049846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 777836..778475
• Replicon: chromosome
• Accession: NZ_CP009799
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CH72_RS19750
• Protein ID: WP_006753827.1
• Coordinates: 777836..778252 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0B8R6
• Locus tag: CH72_RS19755
• Protein ID: WP_006753828.1
• Coordinates: 778239..778475 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH72_RS19715	773191..774354	+	1164	WP_041491473.1	MFS transporter	-
CH72_RS19720	774378..774626	-	249	WP_012366135.1	hypothetical protein	-
CH72_RS19725	774902..775432	-	531	WP_011658903.1	transferase hexapeptide repeat family protein	-
CH72_RS19730	775436..775696	-	261	Protein_661	FAD-binding protein	-
CH72_RS34120	775698..775811	+	114	Protein_662	4-hydroxy-2-oxovalerate aldolase	-
CH72_RS19735	776106..776369	-	264	WP_006751842.1	translation initiation factor IF-1	-
CH72_RS19740	776829..777032	-	204	WP_006751843.1	cold-shock protein	-
CH72_RS19745	777387..777623	-	237	Protein_665	biphenyl 2,3-dioxygenase	-
CH72_RS19750	777836..778252	-	417	WP_006753827.1	type II toxin-antitoxin system VapC family toxin	Toxin
CH72_RS19755	778239..778475	-	237	WP_006753828.1	DNA-binding protein	Antitoxin
CH72_RS19760	778722..779924	-	1203	WP_041491474.1	DUF2029 domain-containing protein	-
CH72_RS19765	780151..781377	+	1227	WP_041491475.1	acyltransferase	-
CH72_RS19775	782102..782971	-	870	WP_011658910.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15295.49 Da
• Isoelectric Point: 6.9900

>T49846 WP_006753827.1 NZ_CP009799:c778252-777836 [Burkholderia ambifaria AMMD]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNI
LPVDIETAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T49846 NZ_CP009799:c778252-777836 [Burkholderia ambifaria AMMD]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCGTTCTTCAG
GCAGGCGGAGGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTGACGGTGGCCGAACTGCGGCGCGGCGTCGACCTGATCC
GTCATCGCGGCGATCATCCGCAGGCGTCGGCGCTCGAGGCATGGATGGCGACGATCCTGTCCGGCTATGCGTCGAACATC
CTGCCCGTCGATATCGAGACCGCCCAGATGTGGGGCCATTTGCGCGTGCCCGATCCGGCCCACGCCCTCGATCACCTGAT
CGCGGCCACCGCGCTGATCAACGATCTGACGGTCGTTACCCGCAATGTCGACGATTTCGCTCGCACCGGCGTCCGGCTGC
TGAACCCGTTCGATTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8682.73 Da
• Isoelectric Point: 5.0774

>AT49846 WP_006753828.1 NZ_CP009799:c778475-778239 [Burkholderia ambifaria AMMD]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT49846 NZ_CP009799:c778475-778239 [Burkholderia ambifaria AMMD]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAACGACGGACATTCGCGCAAGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KQ31