Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 243106..243752 Replicon chromosome
Accession NZ_CP009799
Organism Burkholderia ambifaria AMMD

Toxin (Protein)


Gene name vapC Uniprot ID Q0BA08
Locus tag CH72_RS17615 Protein ID WP_011658486.1
Coordinates 243345..243752 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q0BA09
Locus tag CH72_RS17610 Protein ID WP_011658485.1
Coordinates 243106..243348 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH72_RS17595 239105..240511 + 1407 WP_011658482.1 aspartate ammonia-lyase -
CH72_RS17600 240615..242108 + 1494 WP_011658483.1 amino acid permease -
CH72_RS17605 242152..242841 - 690 WP_041491430.1 phospholipase -
CH72_RS17610 243106..243348 + 243 WP_011658485.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CH72_RS17615 243345..243752 + 408 WP_011658486.1 type II toxin-antitoxin system VapC family toxin Toxin
CH72_RS17620 244202..246592 + 2391 WP_011658487.1 MCP four helix bundle domain-containing protein -
CH72_RS17625 246595..247335 + 741 WP_011658488.1 chemotaxis protein -
CH72_RS17630 247332..247916 + 585 WP_011658489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14843.92 Da        Isoelectric Point: 6.3323

>T49845 WP_011658486.1 NZ_CP009799:243345-243752 [Burkholderia ambifaria AMMD]
MKFLLDTHAVIAILKGEQAMLARLRRHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSFDAEDAQHAGEI
GAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVPELQVEDWLAAAREN

Download         Length: 408 bp

>T49845 NZ_CP009799:243345-243752 [Burkholderia ambifaria AMMD]
ATGAAGTTTCTGCTGGATACCCATGCGGTAATCGCCATTCTGAAAGGCGAACAGGCCATGCTGGCCCGATTGCGTAGACA
TCAACCTGCGGATTTCGGAATTCCCGCGATCGTCGCGCATGAACTCTATTACGGGGCGTACAAGAGTCAGAGAGCGGCAG
CGAATCTGGCACGCGTCGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGATGCGGAAGATGCGCAGCATGCCGGTGAAATC
GGTGCGCAACTGGCCGCGGTGGGAACACCGATCGGGCCATACGATGCATTGATCGCAGGACAGGCGCGAGCGCGACGCCT
GGTGCTTGTCACGCACAACACGCGCGAGTTTGAGCGGGTCCCGGAACTGCAGGTCGAGGATTGGCTCGCGGCGGCGCGCG
AAAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8872.03 Da        Isoelectric Point: 4.7628

>AT49845 WP_011658485.1 NZ_CP009799:243106-243348 [Burkholderia ambifaria AMMD]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAATEPAAQERPGLDVFE

Download         Length: 243 bp

>AT49845 NZ_CP009799:243106-243348 [Burkholderia ambifaria AMMD]
ATGGAGACTGCCAAGATTTTCAAGCATGGTGGATCGCAGGCCGTCCGCTTGCCGAAGGATTTCCGCTTCGATACCACGGA
GGTCCGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAACCGGTGCCGCAAGACTGGGCATGGCTGACACCGTTGATCG
GCCCGGTTGACGCCGATTTTGAGGCCGCCGCGGCAACCGAGCCTGCCGCTCAAGAGCGTCCGGGGCTGGACGTGTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q0BA08

Antitoxin

Source ID Structure
AlphaFold DB A0A3P0NDJ4

References