Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 700428..702172 Replicon chromosome
Accession NZ_CP009793
Organism Burkholderia dolosa AU0158

Toxin (Protein)


Gene name doc Uniprot ID A0A892IG78
Locus tag AK34_RS03085 Protein ID WP_006766124.1
Coordinates 700428..701318 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A892IEP8
Locus tag AK34_RS03090 Protein ID WP_006766123.1
Coordinates 701315..702172 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK34_RS03055 695805..696884 - 1080 WP_035974291.1 porin -
AK34_RS03060 697329..697646 + 318 WP_006766129.1 non-heme iron oxygenase ferredoxin subunit -
AK34_RS03065 697648..697959 + 312 WP_006766128.1 hypothetical protein -
AK34_RS03070 698021..699091 + 1071 WP_006766127.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
AK34_RS03075 699084..699854 + 771 WP_035975317.1 SDR family oxidoreductase -
AK34_RS03080 699882..700409 + 528 WP_035975316.1 cupin domain-containing protein -
AK34_RS03085 700428..701318 + 891 WP_006766124.1 alpha/beta fold hydrolase Toxin
AK34_RS03090 701315..702172 + 858 WP_006766123.1 IclR family transcriptional regulator Antitoxin
AK34_RS03095 702252..703049 + 798 WP_035974289.1 SDR family oxidoreductase -
AK34_RS03100 703042..704709 + 1668 WP_035974287.1 thiamine pyrophosphate-binding protein -
AK34_RS03105 704702..705529 + 828 WP_006766122.1 aspartate dehydrogenase -
AK34_RS03110 705621..707111 + 1491 WP_035974286.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-276)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30188.38 Da        Isoelectric Point: 6.6302

>T49840 WP_006766124.1 NZ_CP009793:700428-701318 [Burkholderia dolosa AU0158]
MTVIEKRERAAAFAALLEQFPEQRCAAGAAGTIGYREAGAQQADRALPVVLLHGIGSGAASWVRQLDALGAVRRVLAWDA
PGYGASTPVRAASPVAADYAAALDAWLDALGIERCVVVGHSLGAIVAGGMVSAMPARIAGLLLISPAGGYGSASADTRNA
RRDARLAMLAALGPAGLAEQRSGNMLSGFASDDARAWVRWNMARIVPDGYAQATHLLANADLAADVAGFAGHAAVAVGAN
DAITPPAACERIAAALGVELQVVPQAGHAGYVEAPAIYSALIDAFCRSCDTQRRPA

Download         Length: 891 bp

>T49840 NZ_CP009793:700428-701318 [Burkholderia dolosa AU0158]
ATGACCGTCATCGAAAAGCGCGAACGCGCAGCGGCTTTCGCCGCGCTGCTCGAGCAGTTTCCGGAGCAGCGCTGCGCGGC
CGGTGCGGCCGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCAAGCGGACCGTGCGCTGCCCGTCGTGCTGCTGCACG
GAATCGGCTCGGGCGCCGCATCGTGGGTGCGTCAGCTCGATGCGCTCGGCGCGGTGCGCCGCGTGCTCGCGTGGGACGCG
CCCGGCTACGGCGCATCGACGCCGGTGCGCGCGGCATCGCCGGTCGCCGCCGATTACGCGGCCGCGCTGGATGCGTGGCT
TGACGCGCTCGGCATCGAGCGCTGCGTGGTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGAGCGCGA
TGCCGGCGCGAATCGCCGGGTTGCTGCTGATCTCGCCGGCGGGCGGCTACGGCAGCGCGAGCGCCGATACGCGCAACGCG
CGCCGCGACGCGCGGCTCGCGATGCTCGCGGCGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAATATGCTGTC
CGGCTTCGCGAGCGACGATGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGACGGCTACGCGCAGGCGA
CGCATCTGCTCGCGAACGCCGATCTGGCGGCCGACGTCGCCGGTTTCGCCGGTCATGCGGCGGTGGCCGTCGGTGCAAAC
GACGCGATCACGCCGCCCGCTGCATGCGAACGGATCGCGGCGGCGCTCGGCGTCGAACTGCAGGTGGTTCCGCAGGCCGG
CCACGCCGGTTACGTCGAAGCGCCGGCCATCTATTCCGCGCTGATCGACGCGTTCTGCCGATCGTGCGACACGCAGCGGA
GGCCCGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31426.97 Da        Isoelectric Point: 8.0592

>AT49840 WP_006766123.1 NZ_CP009793:701315-702172 [Burkholderia dolosa AU0158]
MSAPLQRQAADDAKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYR
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQELYALYPERTLNRMTSATPETVDALYEAIREDARRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 858 bp

>AT49840 NZ_CP009793:701315-702172 [Burkholderia dolosa AU0158]
ATGAGCGCGCCGCTGCAACGCCAGGCAGCCGACGACGCGAAGGCCGATGCCGGCTACGTCGTGCCGGGGCTCGAGCGCGG
GCTGCGGATTCTCGCGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGTATTCCGC
GCACGACGGTGTTTCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGGAACTACCGG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGGCTGCCCGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGC
AAAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGCAGGAGCTGTACGCGCTGTATCCGGAGCGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGCTGTACGAAGCGATCCGCGAAGACGCACGGCGCGGCTACGGGATCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCCGAAATCGACGCGACGCTGATCGCGGACGGACTGATCGACAAGGTGCGGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAGGCTTTGGGACTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References