Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4163756..4164376 Replicon chromosome
Accession NZ_CP009792
Organism Yersinia pseudotuberculosis YPIII

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BZ22_RS19165 Protein ID WP_002208622.1
Coordinates 4164173..4164376 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag BZ22_RS19160 Protein ID WP_002218472.1
Coordinates 4163756..4164124 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ22_RS19140 4161265..4161723 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
BZ22_RS19145 4161961..4162221 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
BZ22_RS19150 4162237..4162380 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BZ22_RS19155 4163244..4163597 + 354 WP_012105569.1 hypothetical protein -
BZ22_RS19160 4163756..4164124 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
BZ22_RS19165 4164173..4164376 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
BZ22_RS19170 4165282..4165671 + 390 WP_024063215.1 MGMT family protein -
BZ22_RS19175 4165807..4166328 - 522 WP_011191872.1 YbaY family lipoprotein -
BZ22_RS19180 4166585..4167445 + 861 WP_002208625.1 acyl-CoA thioesterase II -
BZ22_RS19185 4167706..4168995 - 1290 WP_002228344.1 ammonium transporter AmtB -
BZ22_RS19190 4169035..4169373 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4161265..4161723 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49838 WP_002208622.1 NZ_CP009792:4164173-4164376 [Yersinia pseudotuberculosis YPIII]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49838 NZ_CP009792:4164173-4164376 [Yersinia pseudotuberculosis YPIII]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACTATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT49838 WP_002218472.1 NZ_CP009792:4163756-4164124 [Yersinia pseudotuberculosis YPIII]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT49838 NZ_CP009792:4163756-4164124 [Yersinia pseudotuberculosis YPIII]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References