Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4074622..4075398 Replicon chromosome
Accession NZ_CP009792
Organism Yersinia pseudotuberculosis YPIII

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H3B6R1
Locus tag BZ22_RS18760 Protein ID WP_012304462.1
Coordinates 4074622..4075005 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H3B780
Locus tag BZ22_RS18765 Protein ID WP_012304463.1
Coordinates 4075069..4075398 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ22_RS23335 4070666..4071121 - 456 WP_012304457.1 antitermination protein -
BZ22_RS23480 4071247..4071576 + 330 WP_050756398.1 hypothetical protein -
BZ22_RS18745 4071747..4072901 + 1155 WP_012304459.1 site-specific integrase -
BZ22_RS18750 4073107..4073955 - 849 WP_012304460.1 DUF4942 domain-containing protein -
BZ22_RS18755 4074130..4074625 - 496 Protein_3576 hypothetical protein -
BZ22_RS18760 4074622..4075005 - 384 WP_012304462.1 TA system toxin CbtA family protein Toxin
BZ22_RS18765 4075069..4075398 - 330 WP_012304463.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BZ22_RS18770 4075411..4075881 - 471 WP_012304464.1 DNA repair protein RadC -
BZ22_RS18775 4075952..4076773 - 822 WP_012304465.1 DUF945 domain-containing protein -
BZ22_RS18780 4076862..4077200 - 339 WP_012304466.1 hypothetical protein -
BZ22_RS18785 4077221..4077685 - 465 WP_012304467.1 hypothetical protein -
BZ22_RS18790 4078186..4079073 - 888 WP_012304468.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14442.40 Da        Isoelectric Point: 8.9291

>T49837 WP_012304462.1 NZ_CP009792:c4075005-4074622 [Yersinia pseudotuberculosis YPIII]
MQTLPVNPKRAAQTCPSPVEIWQKLLTHLLDQHYGLTLSDTSFSNETTIREHIDAGISLSYAVNFLVEKYELVRTDRTSF
TIVEQSPFITPIDILRARQATGLLKRSGYKAVSDITRGRARREEQSH

Download         Length: 384 bp

>T49837 NZ_CP009792:c4075005-4074622 [Yersinia pseudotuberculosis YPIII]
ATGCAAACCTTACCCGTAAACCCGAAACGGGCGGCACAAACCTGCCCGTCACCTGTTGAAATATGGCAAAAACTGCTAAC
GCATCTGCTCGATCAACACTATGGACTCACACTTAGTGATACCTCGTTCAGCAATGAAACCACCATCCGTGAACATATTG
ACGCCGGAATATCCCTCAGCTATGCGGTGAACTTCCTGGTGGAAAAATATGAACTGGTACGCACTGACCGGACCAGTTTC
ACCATTGTGGAGCAATCACCGTTTATCACCCCAATCGATATTCTCCGCGCCAGGCAAGCCACCGGTCTCCTGAAGCGCAG
TGGTTATAAAGCCGTCAGTGACATTACCCGTGGCAGAGCTCGGCGAGAGGAGCAAAGCCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12234.84 Da        Isoelectric Point: 6.4825

>AT49837 WP_012304463.1 NZ_CP009792:c4075398-4075069 [Yersinia pseudotuberculosis YPIII]
MSLTLSHEWGLKSDITPRFGARLVQEGNRLHFRADHAGFNGAFSEDEALRLDQAFPLMLKQLELKLLSGELNPRRQHCVT
LNHNGLTCEADTLGSHGYVYITIYPASPE

Download         Length: 330 bp

>AT49837 NZ_CP009792:c4075398-4075069 [Yersinia pseudotuberculosis YPIII]
ATGTCATTAACACTATCCCATGAATGGGGGCTAAAAAGCGATATCACCCCACGCTTTGGCGCAAGATTGGTGCAGGAAGG
CAATCGCCTGCACTTTCGGGCTGACCATGCGGGTTTTAACGGTGCATTCAGTGAGGATGAGGCGCTGCGGCTTGACCAAG
CGTTTCCACTGATGCTCAAACAGCTTGAACTTAAGCTGCTATCCGGTGAGCTCAATCCTCGTCGTCAGCATTGCGTTACG
TTGAACCACAATGGCCTGACCTGCGAAGCTGACACCCTCGGCTCTCACGGGTATGTCTATATCACTATTTACCCGGCAAG
CCCGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3B6R1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3B780

References