Detailed information of TA system TA049828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2755393..2756359
• Replicon: chromosome
• Accession: NZ_CP009792
• Organism: Yersinia pseudotuberculosis YPIII

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: BZ22_RS12615
• Protein ID: WP_011192520.1
• Coordinates: 2755393..2755851 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ22_RS12620
• Protein ID: WP_002210982.1
• Coordinates: 2755913..2756359 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ22_RS12585	2751207..2751872	+	666	WP_011192521.1	phage shock protein PspA	-
BZ22_RS12590	2752034..2752261	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ22_RS12595	2752261..2752620	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
BZ22_RS12600	2752705..2752947	+	243	WP_002216375.1	phage shock protein PspD	-
BZ22_RS12605	2752928..2754325	+	1398	WP_012105043.1	YcjX family protein	-
BZ22_RS12610	2754322..2755383	+	1062	WP_002210980.1	YcjF family protein	-
BZ22_RS12615	2755393..2755851	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
BZ22_RS12620	2755913..2756359	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ22_RS12625	2756696..2758273	+	1578	WP_011192519.1	transcriptional regulator TyrR	-
BZ22_RS12630	2758454..2758957	-	504	WP_002210984.1	thiol peroxidase	-
BZ22_RS12635	2759120..2760094	+	975	WP_012105045.1	L-Ala-D/L-Glu epimerase	-
BZ22_RS12640	2760136..2760843	-	708	WP_032466942.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T49828 WP_011192520.1 NZ_CP009792:c2755851-2755393 [Yersinia pseudotuberculosis YPIII]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49828 NZ_CP009792:c2755851-2755393 [Yersinia pseudotuberculosis YPIII]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49828 WP_002210982.1 NZ_CP009792:c2756359-2755913 [Yersinia pseudotuberculosis YPIII]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49828 NZ_CP009792:c2756359-2755913 [Yersinia pseudotuberculosis YPIII]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGATTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1