Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1653084..1653756 Replicon chromosome
Accession NZ_CP009792
Organism Yersinia pseudotuberculosis YPIII

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag BZ22_RS07455 Protein ID WP_002215144.1
Coordinates 1653331..1653756 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BZ22_RS07450 Protein ID WP_002209939.1
Coordinates 1653084..1653350 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ22_RS07430 1648907..1650010 + 1104 WP_012104675.1 hypothetical protein -
BZ22_RS07435 1650212..1650913 + 702 WP_012303662.1 hemolysin III family protein -
BZ22_RS07440 1651205..1651702 + 498 WP_002209941.1 DUF2165 family protein -
BZ22_RS07445 1651775..1652767 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
BZ22_RS07450 1653084..1653350 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BZ22_RS07455 1653331..1653756 + 426 WP_002215144.1 protein YgfX Toxin
BZ22_RS07460 1653756..1654454 + 699 WP_002209937.1 two-component system response regulator CreB -
BZ22_RS07465 1654479..1655912 + 1434 WP_012104678.1 two-component system sensor histidine kinase CreC -
BZ22_RS07470 1655997..1657454 + 1458 WP_012303664.1 cell envelope integrity protein CreD -
BZ22_RS07475 1657539..1658057 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T49827 WP_002215144.1 NZ_CP009792:1653331-1653756 [Yersinia pseudotuberculosis YPIII]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T49827 NZ_CP009792:1653331-1653756 [Yersinia pseudotuberculosis YPIII]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT49827 WP_002209939.1 NZ_CP009792:1653084-1653350 [Yersinia pseudotuberculosis YPIII]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT49827 NZ_CP009792:1653084-1653350 [Yersinia pseudotuberculosis YPIII]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References