Detailed information of TA system TA049822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1972969..1973497
• Replicon: chromosome
• Accession: NZ_CP009790
• Organism: Xylella fastidiosa strain U24d

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFUD_RS09675
• Protein ID: WP_010894533.1
• Coordinates: 1972969..1973250 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q9PBQ9
• Locus tag: XFUD_RS09680
• Protein ID: WP_010894534.1
• Coordinates: 1973237..1973497 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFUD_RS09625	1968089..1968523	-	435	Protein_1753	hypothetical protein	-
XFUD_RS13730	1968573..1968830	-	258	WP_140190226.1	hypothetical protein	-
XFUD_RS09630	1968985..1969273	-	289	Protein_1755	type II toxin-antitoxin system RelE/ParE family toxin	-
XFUD_RS09635	1969266..1969508	-	243	WP_010894524.1	type II toxin-antitoxin system ParD family antitoxin	-
XFUD_RS09645	1970165..1970461	-	297	WP_010894527.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFUD_RS09650	1970449..1970727	-	279	WP_010894528.1	CopG family ribbon-helix-helix protein	-
XFUD_RS09655	1971259..1971345	+	87	Protein_1759	transposase	-
XFUD_RS09660	1971510..1972169	+	660	WP_010894530.1	hypothetical protein	-
XFUD_RS09665	1972150..1972551	+	402	WP_010894531.1	hypothetical protein	-
XFUD_RS09675	1972969..1973250	-	282	WP_010894533.1	type II toxin-antitoxin system YafQ family toxin	Toxin
XFUD_RS09680	1973237..1973497	-	261	WP_010894534.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XFUD_RS09685	1973827..1974633	-	807	WP_010894535.1	oxidoreductase	-
XFUD_RS09690	1974679..1977741	-	3063	WP_010894536.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10727.49 Da
• Isoelectric Point: 9.0869

>T49822 WP_010894533.1 NZ_CP009790:c1973250-1972969 [Xylella fastidiosa]
VREIKQLGQFKRDLKREAKGQHRATLEDDLLPVIDALAKDMPLEPRHRDHALLGNWKDLRDCHIKLDLVLIYTRVDSKTL
TLVRLGSHAELGL

Nucleotide

• Length: 282 bp

>T49822 NZ_CP009790:c1973250-1972969 [Xylella fastidiosa]
GTGCGGGAAATTAAACAACTCGGGCAGTTCAAACGTGACTTGAAGCGCGAAGCCAAGGGGCAGCATCGCGCCACGCTGGA
AGACGACCTGCTGCCCGTGATCGATGCCCTTGCTAAAGACATGCCCCTTGAGCCTCGGCACAGAGATCACGCACTGCTTG
GCAACTGGAAAGACCTTCGTGATTGTCACATCAAGCTCGACCTAGTCCTGATCTACACGCGGGTGGATAGCAAAACGCTG
ACGCTCGTCCGTCTCGGCTCCCATGCGGAACTCGGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 8997.58 Da
• Isoelectric Point: 10.5972

>AT49822 WP_010894534.1 NZ_CP009790:c1973497-1973237 [Xylella fastidiosa]
MAANQLVQARIDGAIKAEATVVLAAMGLTISDAVRLLLTKVAQDKALPFEPLIPNATTIKAMREARAGKGETVTLGELRA
TIRAGN

Nucleotide

• Length: 261 bp

>AT49822 NZ_CP009790:c1973497-1973237 [Xylella fastidiosa]
ATGGCTGCGAATCAGCTTGTGCAAGCGCGCATCGATGGTGCGATCAAGGCAGAGGCAACCGTGGTACTGGCGGCGATGGG
GTTGACCATTTCCGATGCGGTTCGGCTGTTGCTCACGAAGGTGGCTCAGGACAAGGCGTTGCCTTTTGAGCCGCTAATCC
CTAATGCCACCACCATCAAGGCCATGCGGGAGGCTCGTGCAGGTAAGGGCGAGACCGTCACGCTGGGTGAACTTCGAGCG
ACTATCCGTGCGGGAAATTAA

Structures

Antitoxin

• AlphaFold DB: Q9PBQ9