Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1970165..1970727 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name parE Uniprot ID Q9PBR6
Locus tag XFUD_RS09645 Protein ID WP_010894527.1
Coordinates 1970165..1970461 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9PBR5
Locus tag XFUD_RS09650 Protein ID WP_010894528.1
Coordinates 1970449..1970727 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS09590 1965243..1965452 + 210 WP_010894516.1 hypothetical protein -
XFUD_RS09595 1965482..1966017 - 536 Protein_1747 recombinase family protein -
XFUD_RS09600 1966011..1966214 - 204 WP_023906434.1 hypothetical protein -
XFUD_RS09605 1966266..1966535 - 270 WP_010894518.1 hypothetical protein -
XFUD_RS09610 1966644..1966952 - 309 WP_010894519.1 type II toxin-antitoxin system RelE/ParE family toxin -
XFUD_RS09615 1966956..1967228 - 273 WP_010894520.1 hypothetical protein -
XFUD_RS09620 1967225..1967680 - 456 WP_010894521.1 hypothetical protein -
XFUD_RS09625 1968089..1968523 - 435 Protein_1753 hypothetical protein -
XFUD_RS13730 1968573..1968830 - 258 WP_140190226.1 hypothetical protein -
XFUD_RS09630 1968985..1969273 - 289 Protein_1755 type II toxin-antitoxin system RelE/ParE family toxin -
XFUD_RS09635 1969266..1969508 - 243 WP_010894524.1 type II toxin-antitoxin system ParD family antitoxin -
XFUD_RS09645 1970165..1970461 - 297 WP_010894527.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFUD_RS09650 1970449..1970727 - 279 WP_010894528.1 CopG family ribbon-helix-helix protein Antitoxin
XFUD_RS09655 1971259..1971345 + 87 Protein_1759 transposase -
XFUD_RS09660 1971510..1972169 + 660 WP_010894530.1 hypothetical protein -
XFUD_RS09665 1972150..1972551 + 402 WP_010894531.1 hypothetical protein -
XFUD_RS09675 1972969..1973250 - 282 WP_010894533.1 type II toxin-antitoxin system YafQ family toxin -
XFUD_RS09680 1973237..1973497 - 261 WP_010894534.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
XFUD_RS09685 1973827..1974633 - 807 WP_010894535.1 oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11155.72 Da        Isoelectric Point: 7.4670

>T49821 WP_010894527.1 NZ_CP009790:c1970461-1970165 [Xylella fastidiosa]
MPRVIFAPEAILNIQRLRNFLHPKNTDAARRAGEAIMRGARMLGAQPHIGRPVDDMPDEYREWLIDFGDSGYVARYHIDG
DTVTILAVRHHKEVGYTS

Download         Length: 297 bp

>T49821 NZ_CP009790:c1970461-1970165 [Xylella fastidiosa]
ATGCCACGGGTGATCTTCGCTCCCGAAGCCATCCTGAACATTCAACGATTGCGGAATTTCCTGCATCCGAAGAACACCGA
TGCCGCAAGGCGGGCCGGTGAAGCCATCATGCGGGGTGCGCGGATGCTTGGAGCGCAGCCACATATCGGTCGTCCGGTTG
ATGATATGCCCGATGAGTACAGGGAATGGCTGATTGACTTCGGAGATAGCGGTTATGTGGCCCGCTACCACATTGATGGC
GATACCGTCACGATCTTGGCTGTTCGACACCATAAGGAAGTGGGATACACCAGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10772.08 Da        Isoelectric Point: 5.6126

>AT49821 WP_010894528.1 NZ_CP009790:c1970727-1970449 [Xylella fastidiosa]
MGMATSIKLDDELKGRVQHLADVRRRTSHWIMREAIAQYVEREEKRETFRQDTLKAWEEFQATGLHVTTEEVEKWLSSWG
TENELSAPVCHG

Download         Length: 279 bp

>AT49821 NZ_CP009790:c1970727-1970449 [Xylella fastidiosa]
ATGGGCATGGCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGTGTGCAGCATCTGGCCGATGTTCGCCGCCGCAC
TTCGCACTGGATCATGCGCGAGGCGATCGCGCAGTACGTTGAGCGTGAGGAAAAGCGTGAGACGTTTCGGCAGGACACGC
TGAAGGCATGGGAAGAGTTTCAGGCGACCGGCCTGCACGTGACGACCGAAGAAGTCGAGAAGTGGCTTTCGAGTTGGGGC
ACTGAAAATGAATTGTCAGCGCCCGTATGCCACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S0VAK4

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V821

References