Detailed information of TA system TA049818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1620802..1621288
• Replicon: chromosome
• Accession: NZ_CP009790
• Organism: Xylella fastidiosa strain U24d

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: XFUD_RS07730
• Protein ID: WP_042463219.1
• Coordinates: 1620802..1621077 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1L2AR28
• Locus tag: XFUD_RS07735
• Protein ID: WP_031336679.1
• Coordinates: 1621061..1621288 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFUD_RS07700	1616953..1617390	+	438	WP_010894081.1	DUF3277 family protein	-
XFUD_RS07705	1617387..1617809	+	423	WP_010894082.1	hypothetical protein	-
XFUD_RS07710	1617957..1619846	+	1890	WP_010894164.1	hypothetical protein	-
XFUD_RS07715	1620176..1620352	+	177	WP_088371569.1	Blp family class II bacteriocin	-
XFUD_RS07720	1620386..1620574	+	189	WP_010894166.1	hypothetical protein	-
XFUD_RS07725	1620579..1620749	-	171	WP_010894167.1	antitoxin	-
XFUD_RS07730	1620802..1621077	-	276	WP_042463219.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFUD_RS07735	1621061..1621288	-	228	WP_031336679.1	CopG family transcriptional regulator	Antitoxin
XFUD_RS07740	1621399..1622169	+	771	WP_010894169.1	hypothetical protein	-
XFUD_RS07745	1622169..1622486	+	318	WP_010894170.1	hypothetical protein	-
XFUD_RS07750	1622483..1623313	+	831	WP_010894171.1	hypothetical protein	-
XFUD_RS07755	1623310..1623951	+	642	WP_010894172.1	hypothetical protein	-
XFUD_RS07760	1623948..1624301	+	354	WP_010894173.1	hypothetical protein	-
XFUD_RS07765	1624312..1624617	-	306	WP_004089254.1	putative addiction module antidote protein	-
XFUD_RS07770	1624614..1624916	-	303	WP_042463224.1	type II toxin-antitoxin system RelE/ParE family toxin	-
XFUD_RS07775	1625015..1626160	+	1146	WP_042463227.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585967..1628396	42429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10471.13 Da
• Isoelectric Point: 10.0494

>T49818 WP_042463219.1 NZ_CP009790:c1621077-1620802 [Xylella fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVGV
GHRGEMYRREC

Nucleotide

• Length: 276 bp

>T49818 NZ_CP009790:c1621077-1620802 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAACTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTGGTGGGTGTT
GGTCACCGGGGTGAGATGTACCGACGAGAATGCTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8691.73 Da
• Isoelectric Point: 5.0958

>AT49818 WP_031336679.1 NZ_CP009790:c1621288-1621061 [Xylella fastidiosa]
MATSIRLSPEMEQRLNYLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT49818 NZ_CP009790:c1621288-1621061 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTATCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTATTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1L2AR28