Detailed information of TA system TA049816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1603436..1604022
• Replicon: chromosome
• Accession: NZ_CP009790
• Organism: Xylella fastidiosa strain U24d

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: XFUD_RS07595
• Protein ID: WP_080507210.1
• Coordinates: 1603436..1603690 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2I6C9
• Locus tag: XFUD_RS07600
• Protein ID: WP_004085025.1
• Coordinates: 1603687..1604022 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFUD_RS07560	1598496..1598879	+	384	WP_042463212.1	hypothetical protein	-
XFUD_RS07565	1599083..1600195	+	1113	WP_042463693.1	Bro-N domain-containing protein	-
XFUD_RS07570	1600192..1600500	+	309	WP_023906549.1	DUF1376 domain-containing protein	-
XFUD_RS07575	1600497..1601585	+	1089	WP_010894160.1	YdaU family protein	-
XFUD_RS07580	1601491..1602255	+	765	WP_195780003.1	hypothetical protein	-
XFUD_RS07585	1602252..1602665	+	414	WP_010894161.1	hypothetical protein	-
XFUD_RS07590	1602685..1603383	+	699	WP_042463215.1	hypothetical protein	-
XFUD_RS07595	1603436..1603690	+	255	WP_080507210.1	type II toxin-antitoxin system HicA family toxin	Toxin
XFUD_RS07600	1603687..1604022	+	336	WP_004085025.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
XFUD_RS07605	1604284..1604781	+	498	WP_042463169.1	lysozyme	-
XFUD_RS07610	1604774..1605103	+	330	WP_010894063.1	phage holin family protein	-
XFUD_RS07615	1605093..1605554	+	462	WP_010894064.1	hypothetical protein	-
XFUD_RS07620	1605556..1605768	+	213	WP_042463172.1	hypothetical protein	-
XFUD_RS07625	1605859..1606257	+	399	WP_010894066.1	hypothetical protein	-
XFUD_RS07630	1606208..1607758	+	1551	Protein_1374	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585967..1628396	42429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9621.10 Da
• Isoelectric Point: 11.2766

>T49816 WP_080507210.1 NZ_CP009790:1603436-1603690 [Xylella fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRILVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T49816 NZ_CP009790:1603436-1603690 [Xylella fastidiosa]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATATTGGTGAGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12324.07 Da
• Isoelectric Point: 5.6556

>AT49816 WP_004085025.1 NZ_CP009790:1603687-1604022 [Xylella fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Nucleotide

• Length: 336 bp

>AT49816 NZ_CP009790:1603687-1604022 [Xylella fastidiosa]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAAATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Structures

Antitoxin

• AlphaFold DB: A0A060HAK5