Detailed information of TA system TA049815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1595533..1596329
• Replicon: chromosome
• Accession: NZ_CP009790
• Organism: Xylella fastidiosa strain U24d

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: Q9PCU8
• Locus tag: XFUD_RS07525
• Protein ID: WP_010894152.1
• Coordinates: 1595718..1596329 (+)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: Q9PCU9
• Locus tag: XFUD_RS07520
• Protein ID: WP_010894151.1
• Coordinates: 1595533..1595721 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFUD_RS07480	1591158..1592084	-	927	WP_010894143.1	phage recombination protein Bet	-
XFUD_RS07485	1592100..1592921	-	822	WP_010894144.1	YfdQ family protein	-
XFUD_RS07490	1592942..1593316	-	375	WP_010894145.1	hypothetical protein	-
XFUD_RS07495	1593337..1593528	-	192	WP_010894146.1	hypothetical protein	-
XFUD_RS07500	1593552..1593743	-	192	WP_010894147.1	hypothetical protein	-
XFUD_RS07505	1593740..1594141	-	402	WP_010894148.1	hypothetical protein	-
XFUD_RS07510	1594141..1594599	-	459	WP_010894149.1	hypothetical protein	-
XFUD_RS07515	1594596..1595141	-	546	WP_080507209.1	hypothetical protein	-
XFUD_RS07520	1595533..1595721	+	189	WP_010894151.1	antitoxin VbhA family protein	Antitoxin
XFUD_RS07525	1595718..1596329	+	612	WP_010894152.1	Fic/DOC family protein	Toxin
XFUD_RS07530	1596380..1597054	-	675	WP_042463200.1	helix-turn-helix transcriptional regulator	-
XFUD_RS07535	1597139..1597384	+	246	WP_042463203.1	hypothetical protein	-
XFUD_RS07540	1597381..1597686	-	306	WP_042463205.1	hypothetical protein	-
XFUD_RS07545	1597827..1598012	+	186	Protein_1357	hypothetical protein	-
XFUD_RS07550	1598066..1598254	+	189	WP_042463208.1	hypothetical protein	-
XFUD_RS07555	1598251..1598499	+	249	WP_010894156.1	hypothetical protein	-
XFUD_RS07560	1598496..1598879	+	384	WP_042463212.1	hypothetical protein	-
XFUD_RS07565	1599083..1600195	+	1113	WP_042463693.1	Bro-N domain-containing protein	-
XFUD_RS07570	1600192..1600500	+	309	WP_023906549.1	DUF1376 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585967..1628396	42429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22892.65 Da
• Isoelectric Point: 4.9498

>T49815 WP_010894152.1 NZ_CP009790:1595718-1596329 [Xylella fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGISDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T49815 NZ_CP009790:1595718-1596329 [Xylella fastidiosa]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGCGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGCCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAGGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTTCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATCGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGCGGATTGGC
TAGTATCATTCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6885.83 Da
• Isoelectric Point: 4.9859

>AT49815 WP_010894151.1 NZ_CP009790:1595533-1595721 [Xylella fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIATAVDQYKARVRLQMA

Nucleotide

• Length: 189 bp

>AT49815 NZ_CP009790:1595533-1595721 [Xylella fastidiosa]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAGGCCGTGGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTACCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA

Structures

Toxin

• AlphaFold DB: Q9PCU8

Antitoxin

• AlphaFold DB: Q9PCU9