Detailed information of TA system TA049780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 3175982..3176487
• Replicon: chromosome
• Accession: NZ_CP009788
• Organism: Geobacter pickeringii strain G13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPICK_RS17125
• Protein ID: WP_084201451.1
• Coordinates: 3176233..3176487 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0B5BGX2
• Locus tag: GPICK_RS14445
• Protein ID: WP_039744352.1
• Coordinates: 3175982..3176236 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPICK_RS14420	3171473..3172066	+	594	WP_039744345.1	cytochrome c oxidase subunit 3 family protein	-
GPICK_RS14425	3172070..3172333	+	264	WP_039744347.1	cytochrome C oxidase subunit IV family protein	-
GPICK_RS14430	3172354..3173208	+	855	WP_039744349.1	COX15/CtaA family protein	-
GPICK_RS14435	3173208..3174095	+	888	WP_052263453.1	heme o synthase	-
GPICK_RS17450	3174671..3175360	+	690	WP_144400105.1	hypothetical protein	-
GPICK_RS14440	3175497..3175871	+	375	WP_039744350.1	hypothetical protein	-
GPICK_RS14445	3175982..3176236	+	255	WP_039744352.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GPICK_RS17125	3176233..3176487	+	255	WP_084201451.1	Txe/YoeB family addiction module toxin	Toxin
GPICK_RS14455	3176536..3176868	-	333	WP_039745839.1	hydrogenase maturation nickel metallochaperone HypA	-
GPICK_RS14460	3177034..3178458	+	1425	WP_039744356.1	HAMP domain-containing protein	-
GPICK_RS14465	3178455..3179822	+	1368	WP_039744357.1	sigma-54 dependent transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10101.56 Da
• Isoelectric Point: 7.8531

>T49780 WP_084201451.1 NZ_CP009788:3176233-3176487 [Geobacter pickeringii]
MNVTFTPTALDDLRYWLKTDKRQADRIFALLEEIRRTPFDGTGKPEPLRFQLAGCWSRRIDREHRLVYQVEESEIVVIAC
RYHY

Nucleotide

• Length: 255 bp

>T49780 NZ_CP009788:3176233-3176487 [Geobacter pickeringii]
ATGAATGTCACATTCACTCCGACCGCACTCGATGACCTGCGTTACTGGCTAAAGACCGACAAACGTCAGGCTGACCGAAT
TTTCGCTCTTCTCGAAGAGATTCGTCGCACCCCTTTCGATGGGACCGGAAAACCGGAGCCGCTCCGCTTCCAGCTTGCGG
GTTGCTGGTCCCGTCGGATCGACCGCGAACATCGTCTCGTATATCAGGTTGAAGAAAGCGAGATTGTCGTCATCGCCTGT
CGTTACCATTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9476.71 Da
• Isoelectric Point: 4.4915

>AT49780 WP_039744352.1 NZ_CP009788:3175982-3176236 [Geobacter pickeringii]
MNAITYSEARHSLKDVMDEACNNHEPILITRRKGENVVLLSLEDYESIMESEYLLSNPANAARLMQSLEEARAGKRTPLD
ALDL

Nucleotide

• Length: 255 bp

>AT49780 NZ_CP009788:3175982-3176236 [Geobacter pickeringii]
ATGAACGCGATTACCTATAGCGAAGCTCGTCATTCTTTAAAGGATGTCATGGACGAAGCTTGTAACAACCACGAACCAAT
ACTGATTACGCGTCGAAAAGGAGAGAACGTCGTCCTGTTGAGCCTTGAAGACTATGAGTCCATCATGGAAAGCGAATATC
TGCTGTCCAACCCTGCCAATGCCGCACGGCTCATGCAATCGCTTGAAGAAGCCCGGGCGGGGAAACGTACCCCCCTGGAT
GCCCTTGATCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0B5BGX2