Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4052855..4053474 Replicon chromosome
Accession NZ_CP009787
Organism Yersinia rohdei strain YRA

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH64_RS17800 Protein ID WP_002208622.1
Coordinates 4052855..4053058 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0U1HRM3
Locus tag CH64_RS17805 Protein ID WP_032816856.1
Coordinates 4053106..4053474 (-) Length 123 a.a.

Genomic Context

CH64_RS17775CH64_RS17780CH64_RS17790CH64_RS17815CH64_RS17820CH64_RS17825CH64_RS17785CH64_RS17795CH64_RS17800CH64_RS17805CH64_RS17810CH64_RS17830CH64_RS17835
Location: 4048045..4048383 (339 bp)
Type: Others
Protein ID: WP_002208627.1
Location: 4048423..4049712 (1290 bp)
Type: Others
Protein ID: WP_032816887.1
Location: 4051012..4051536 (525 bp)
Type: Others
Protein ID: WP_004714596.1
Location: 4054738..4055469 (732 bp)
Type: Others
Protein ID: WP_072086988.1
Location: 4055469..4056326 (858 bp)
Type: Others
Protein ID: WP_004714601.1
Location: 4056359..4057240 (882 bp)
Type: Others
Protein ID: WP_004714602.1
Location: 4049898..4050764 (867 bp)
Type: Others
Protein ID: WP_004714595.1
Location: 4051582..4051890 (309 bp)
Type: Others
Protein ID: WP_145522794.1
Location: 4052855..4053058 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 4053106..4053474 (369 bp)
Type: Antitoxin
Protein ID: WP_032816856.1
Location: 4053633..4053986 (354 bp)
Type: Others
Protein ID: WP_004714600.1
Location: 4057360..4057503 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 4057519..4057779 (261 bp)
Type: Others
Protein ID: WP_004714603.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CH64_RS177754048045..4048383+339WP_002208627.1P-II family nitrogen regulator-
CH64_RS177804048423..4049712+1290WP_032816887.1ammonium transporter AmtB-
CH64_RS177854049898..4050764-867WP_004714595.1acyl-CoA thioesterase II-
CH64_RS177904051012..4051536+525WP_004714596.1YbaY family lipoprotein-
CH64_RS177954051582..4051890-309WP_145522794.1MGMT family protein-
CH64_RS178004052855..4053058-204WP_002208622.1expression modulating protein YmoAToxin
CH64_RS178054053106..4053474-369WP_032816856.1Hha toxicity modulator TomBAntitoxin
CH64_RS178104053633..4053986-354WP_004714600.1hypothetical protein-
CH64_RS178154054738..4055469+732WP_072086988.1ABC transporter ATP-binding protein-
CH64_RS178204055469..4056326+858WP_004714601.1metal ABC transporter permease-
CH64_RS178254056359..4057240+882WP_004714602.1metal ABC transporter substrate-binding protein-
CH64_RS178304057360..4057503-144WP_002208618.1type B 50S ribosomal protein L36-
CH64_RS178354057519..4057779-261WP_004714603.1type B 50S ribosomal protein L31-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T49777 WP_002208622.1 NZ_CP009787:c4053058-4052855 [Yersinia rohdei]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T49777 NZ_CP009787:c4053058-4052855 [Yersinia rohdei]
ATGACAAAGACTGACTATCTAATGCGTTTAAGAAAATGTACGACTATCGATACATTAGAGCGCGTAATTGAAAAAAATAA
GTATGAGCTTTCAGATGATGAGTTGGAATTATTTTACTCAGCCGCTGACCATCGTTTAGCTGAACTCACTATGAATAAGC
TTTATGATAAAATTCCCCCTACCGTCTGGCAACATGTAAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14171.93 Da        Isoelectric Point: 4.5221

>AT49777 WP_032816856.1 NZ_CP009787:c4053474-4053106 [Yersinia rohdei]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGELSELVEEYL
DDTYTLFSSYGINDPELHRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT49777 NZ_CP009787:c4053474-4053106 [Yersinia rohdei]
ATGGATGAGTACTCACCTAAGCGGCATGATATTGCCCAATTGAAGTTTCTATGTGAGAGTTTGTATGATGAAGGTATCGC
CACCCTCGGTGATAGTCACCATGGCTGGGTAAATGACCCGACATCTGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCCGATGGCGGTGAACTGTCAGAGTTAGTTGAAGAATATTTA
GACGATACATATACTTTGTTTAGTAGTTATGGGATCAACGATCCTGAATTGCACCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTATTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB2K5S

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0U1HRM3

References