Detailed information of TA system TA049776

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yafW/CbtA-CbeA
• Location: 2288421..2289143
• Replicon: chromosome
• Accession: NZ_CP009787
• Organism: Yersinia rohdei strain YRA

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CH64_RS10165
• Protein ID: WP_032816784.1
• Coordinates: 2288421..2288741 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yafW
• Uniprot ID: -
• Locus tag: CH64_RS10170
• Protein ID: WP_032816785.1
• Coordinates: 2288808..2289143 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH64_RS10150	2285232..2287070	+	1839	WP_004714524.1	RNA polymerase sigma factor RpoD	-
CH64_RS10160	2287474..2288307	-	834	WP_004714525.1	DUF4942 domain-containing protein	-
CH64_RS10165	2288421..2288741	-	321	WP_032816784.1	TA system toxin CbtA family protein	Toxin
CH64_RS10170	2288808..2289143	-	336	WP_032816785.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CH64_RS10175	2289157..2289636	-	480	WP_004714528.1	DNA repair protein RadC	-
CH64_RS10185	2290771..2292201	+	1431	WP_004714530.1	hypothetical protein	-
CH64_RS10190	2292604..2293779	+	1176	WP_004714531.1	SAVED domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12117.79 Da
• Isoelectric Point: 6.2084

>T49776 WP_032816784.1 NZ_CP009787:c2288741-2288421 [Yersinia rohdei]
MHISTVPATMPVSSRLSPIQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIHEHIEAGITLADAVNFLVERYELIRTDRKGF
TWQEQTPFLTATDILRAKRATGLMNT

Nucleotide

• Length: 321 bp

>T49776 NZ_CP009787:c2288741-2288421 [Yersinia rohdei]
ATGCATATCTCAACTGTACCGGCCACGATGCCGGTTTCATCACGCCTGTCTCCCATCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTCACACTCAACGATACACCATTCCACGATGATTCAGCTATTCATGAGCACATCG
AAGCGGGAATAACGCTTGCTGATGCGGTGAATTTCCTTGTGGAACGCTATGAACTGATACGCACTGACCGTAAAGGGTTT
ACATGGCAGGAGCAGACACCGTTCCTGACCGCTACCGATATTCTCAGAGCAAAGCGAGCTACCGGATTAATGAATACGTA
A

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12334.02 Da
• Isoelectric Point: 5.9588

>AT49776 WP_032816785.1 NZ_CP009787:c2289143-2288808 [Yersinia rohdei]
MNNDATPALGLKREITPCFGARLVQEGHRLHFLADRAGFNGSFSEMQARDLDEAFPHFVAHTELMLLSGELNPRCAYCVA
LYRNELTCEADTLGSHGYVYIAIYPSNLVKA

Nucleotide

• Length: 336 bp

>AT49776 NZ_CP009787:c2289143-2288808 [Yersinia rohdei]
ATGAATAACGACGCTACCCCAGCCTTGGGTCTTAAACGAGAGATCACGCCGTGTTTTGGAGCACGGCTGGTGCAGGAAGG
TCATCGTCTGCATTTTCTGGCAGACCGGGCAGGATTCAACGGTTCATTCAGCGAGATGCAGGCCCGAGATCTGGATGAAG
CCTTTCCGCATTTTGTCGCGCATACGGAATTGATGCTGCTCTCCGGTGAGCTGAATCCCCGGTGCGCATACTGCGTCGCG
CTGTACCGTAACGAGCTGACCTGTGAAGCCGATACGCTGGGCAGTCATGGGTATGTGTATATCGCAATTTATCCCTCAAA
TCTGGTTAAAGCCTGA