49775

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1962972..1963647 Replicon chromosome
Accession NZ_CP009787
Organism Yersinia rohdei strain YRA

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1HWY2
Locus tag CH64_RS08730 Protein ID WP_032818370.1
Coordinates 1962972..1963400 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0U1HWX1
Locus tag CH64_RS08735 Protein ID WP_004716765.1
Coordinates 1963381..1963647 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH64_RS08710 1958643..1960376 - 1734 WP_004716760.1 single-stranded-DNA-specific exonuclease RecJ -
CH64_RS08715 1960383..1961096 - 714 WP_004716761.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CH64_RS08720 1961127..1962026 - 900 WP_004716762.1 site-specific tyrosine recombinase XerD -
CH64_RS08725 1962133..1962651 + 519 WP_032818368.1 flavodoxin FldB -
CH64_RS08730 1962972..1963400 - 429 WP_032818370.1 protein YgfX Toxin
CH64_RS08735 1963381..1963647 - 267 WP_004716765.1 FAD assembly factor SdhE Antitoxin
CH64_RS08740 1963842..1964825 + 984 WP_004716766.1 tRNA-modifying protein YgfZ -
CH64_RS20160 1965062..1965307 + 246 WP_144404254.1 hypothetical protein -
CH64_RS08745 1965421..1967889 - 2469 WP_144404255.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16613.53 Da        Isoelectric Point: 10.5314

>T49775 WP_032818370.1 NZ_CP009787:c1963400-1962972 [Yersinia rohdei]
VAQWRCDLRVSWHTQLFSLLTHGVLVILTLVAPWPQGYTAFWLVLLTLVVFECIRSQKKITSCQGEIRLKPGNVVLWKRH
EWLVVKQPWITRYGVLLSLRQASSRSTRKRLWLAADSMSEDEWRQLCLLLRHSFGSDEGIKQ

Download         Length: 429 bp

>T49775 NZ_CP009787:c1963400-1962972 [Yersinia rohdei]
GTGGCCCAGTGGAGATGTGACCTGCGGGTATCCTGGCATACTCAATTATTCTCATTATTAACACATGGCGTTTTAGTCAT
ACTTACGTTAGTTGCGCCTTGGCCGCAGGGCTATACCGCATTTTGGTTGGTATTACTGACGCTGGTGGTTTTTGAGTGTA
TCCGCAGCCAGAAAAAAATCACTTCTTGTCAGGGCGAAATTAGGCTGAAACCCGGCAATGTGGTGTTATGGAAAAGACAC
GAATGGCTGGTAGTGAAACAGCCGTGGATAACTCGTTATGGCGTGTTATTAAGTTTACGACAGGCAAGTAGCCGCTCTAC
GCGTAAACGTTTATGGCTGGCTGCTGACAGCATGTCAGAAGACGAGTGGCGACAACTGTGCCTGCTGCTGCGTCATTCAT
TCGGTTCTGATGAGGGTATCAAGCAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10564.06 Da        Isoelectric Point: 4.7010

>AT49775 WP_004716765.1 NZ_CP009787:c1963647-1963381 [Yersinia rohdei]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSESEKQTFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVEM

Download         Length: 267 bp

>AT49775 NZ_CP009787:c1963647-1963381 [Yersinia rohdei]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGTGGAATGCGTGAACTTGATATCTCTATCATGCCATT
TTTTGAGTATGAATATGATGGCCTGAGCGAGAGCGAAAAGCAGACTTTTATCCGCCTGCTTGAATGTGATGATCCAGATT
TATTTAACTGGCTGATGAACCACGGGGAACCGCAGGACAGCGAACTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGAGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1HWY2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1HWX1

References