Detailed information of TA system TA049774

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1736617..1737298
• Replicon: chromosome
• Accession: NZ_CP009787
• Organism: Yersinia rohdei strain YRA

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CH64_RS07650
• Protein ID: WP_032816429.1
• Coordinates: 1736978..1737298 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CH64_RS07645
• Protein ID: WP_004714012.1
• Coordinates: 1736617..1736940 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH64_RS07615	1732331..1733206	+	876	WP_032816426.1	GTPase family protein	-
CH64_RS07620	1733419..1734108	+	690	WP_004714007.1	WYL domain-containing protein	-
CH64_RS07625	1734216..1734632	+	417	WP_004714008.1	hypothetical protein	-
CH64_RS07630	1734678..1735145	+	468	WP_200891553.1	hypothetical protein	-
CH64_RS07635	1735242..1736063	+	822	WP_032816428.1	DUF945 domain-containing protein	-
CH64_RS07640	1736134..1736604	+	471	WP_004714011.1	DNA repair protein RadC	-
CH64_RS07645	1736617..1736940	+	324	WP_004714012.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CH64_RS07650	1736978..1737298	+	321	WP_032816429.1	TA system toxin CbtA family protein	Toxin
CH64_RS07655	1738218..1738658	+	441	WP_004714015.1	hypothetical protein	-
CH64_RS07660	1738658..1738978	+	321	WP_032816430.1	DUF1493 family protein	-
CH64_RS07665	1739011..1739319	-	309	WP_081452038.1	tail fiber assembly protein	-
CH64_RS07670	1739469..1740236	-	768	WP_032816431.1	hypothetical protein	-
CH64_RS07675	1741050..1741832	-	783	WP_004714018.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-105)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11987.61 Da
• Isoelectric Point: 5.9637

>T49774 WP_032816429.1 NZ_CP009787:1736978-1737298 [Yersinia rohdei]
MHISSVPATVSVSSRLSPVQVWQQLLTYLLEHHYGLKLNDTPFHEDTAIEEHIDAGITLAEAVNFLVERYELVRIDRKGS
TWQEQTPFLTATDILRAKRATGIIST

Nucleotide

• Length: 321 bp

>T49774 NZ_CP009787:1736978-1737298 [Yersinia rohdei]
ATGCACATTTCATCTGTACCGGCCACGGTGTCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTGTGGCAGCAATTGTTAAC
GTATCTGCTGGAGCACCATTACGGCCTGAAGCTTAACGACACGCCATTCCATGAAGACACGGCCATTGAGGAGCATATCG
ATGCAGGAATCACGCTCGCCGAAGCTGTTAATTTTCTGGTGGAACGTTATGAACTGGTACGCATCGACCGTAAGGGATCC
ACTTGGCAAGAGCAAACACCATTCCTGACCGCCACCGACATTCTCAGAGCCAAGCGAGCTACGGGGATAATAAGCACTTA
A

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12015.73 Da
• Isoelectric Point: 6.7470

>AT49774 WP_004714012.1 NZ_CP009787:1736617-1736940 [Yersinia rohdei]
MPFTPSHEWGLQSDITPRFGARLVQEGNRLHYLADRAGLTGSFSPIHLQKLDLAFPLFVEQLENMLRAGELNPHQQHQVI
IHLTGLTCIADTRGSCGYVYISIYPAQ

Nucleotide

• Length: 324 bp

>AT49774 NZ_CP009787:1736617-1736940 [Yersinia rohdei]
ATGCCATTTACACCATCCCATGAGTGGGGGTTACAAAGCGATATCACCCCAAGATTTGGAGCCAGATTAGTTCAGGAAGG
CAACAGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGTTTTAGCCCGATACATCTGCAGAAATTAGATCTGG
CTTTCCCGCTATTTGTAGAACAACTGGAAAATATGCTGCGTGCTGGCGAACTAAATCCACATCAGCAACATCAGGTGATC
ATTCATCTTACGGGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCAATTTATCCAGCCCA
GTAA