Detailed information of TA system TA049773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1534455..1534990
• Replicon: chromosome
• Accession: NZ_CP009787
• Organism: Yersinia rohdei strain YRA

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0U1HV74
• Locus tag: CH64_RS06820
• Protein ID: WP_032817448.1
• Coordinates: 1534455..1534742 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CH64_RS06825
• Protein ID: WP_004715706.1
• Coordinates: 1534739..1534990 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH64_RS06800	1529749..1530675	+	927	WP_004715703.1	oxygen-dependent coproporphyrinogen oxidase	-
CH64_RS06805	1530675..1531154	+	480	WP_032817446.1	YaiI/YqxD family protein	-
CH64_RS06810	1531278..1533557	-	2280	WP_004715704.1	NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase	-
CH64_RS06815	1533836..1534411	-	576	WP_004715705.1	GDP-mannose pyrophosphatase NudK	-
CH64_RS06820	1534455..1534742	-	288	WP_032817448.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH64_RS06825	1534739..1534990	-	252	WP_004715706.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CH64_RS06830	1535134..1535733	-	600	WP_004715707.1	cytochrome c-type protein NapC	-
CH64_RS06835	1535761..1536228	-	468	WP_004715708.1	nitrate reductase cytochrome c-type subunit	-
CH64_RS06840	1536323..1538818	-	2496	WP_032817450.1	nitrate reductase catalytic subunit NapA	-
CH64_RS06845	1538815..1539081	-	267	WP_032817452.1	chaperone NapD	-
CH64_RS06850	1539071..1539574	-	504	WP_004715711.1	ferredoxin-type protein NapF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11043.87 Da
• Isoelectric Point: 9.9807

>T49773 WP_032817448.1 NZ_CP009787:c1534742-1534455 [Yersinia rohdei]
MIYTVKFREEALKEWHNLDKTIQQQFANKLKKCTDNPHIESARLRGMKDCYNIKLGSSGFRLVYEVIDDVLIIAVVAVGK
RDRKAVYTLASDRLR

Nucleotide

• Length: 288 bp

>T49773 NZ_CP009787:c1534742-1534455 [Yersinia rohdei]
ATGATTTATACCGTTAAGTTCAGAGAAGAAGCGCTAAAGGAATGGCACAACCTGGATAAGACGATACAACAACAGTTCGC
CAATAAATTAAAGAAATGTACTGATAATCCGCATATTGAAAGCGCCAGACTGCGGGGAATGAAAGATTGCTACAATATTA
AATTAGGTTCCTCTGGCTTTCGATTAGTGTATGAAGTTATCGATGATGTTTTGATCATTGCAGTGGTTGCGGTTGGAAAA
AGAGATCGTAAGGCAGTTTATACACTCGCAAGTGATAGATTGCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9107.40 Da
• Isoelectric Point: 4.3287

>AT49773 WP_004715706.1 NZ_CP009787:c1534990-1534739 [Yersinia rohdei]
MPSIILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPVFYCVPAELYEQIMGALDDHELAKLVNERRHQPLLDADLD
SEL

Nucleotide

• Length: 252 bp

>AT49773 NZ_CP009787:c1534990-1534739 [Yersinia rohdei]
ATGCCAAGTATCATTTTGACTGATACCAGTGCGAGTGTGAGTGAATTGAAGAAAAACCCAATGGCAACAGTCAATGCCGG
GGCTGGATTTCCCGTTGCTATACTCAATCGCAATCAACCCGTCTTTTATTGCGTCCCAGCAGAACTTTATGAGCAAATAA
TGGGTGCACTTGATGATCATGAATTAGCTAAATTGGTTAATGAGCGCCGTCATCAACCATTGCTGGATGCAGACTTGGAT
AGCGAACTATGA

Structures

Toxin

• AlphaFold DB: A0A0U1HV74