Detailed information of TA system TA049764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 738745..739736
• Replicon: chromosome
• Accession: NZ_CP009787
• Organism: Yersinia rohdei strain YRA

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CH64_RS03225
• Protein ID: WP_004712918.1
• Coordinates: 739278..739736 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0U1HPA3
• Locus tag: CH64_RS03220
• Protein ID: WP_004712916.1
• Coordinates: 738745..739191 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH64_RS03200	734357..735064	+	708	WP_032816028.1	murein tripeptide amidase MpaA	-
CH64_RS03205	735061..736032	-	972	WP_004712913.1	L-Ala-D/L-Glu epimerase	-
CH64_RS03210	736185..736688	+	504	WP_032815855.1	thiol peroxidase	-
CH64_RS03215	736848..738425	-	1578	WP_032815856.1	transcriptional regulator TyrR	-
CH64_RS03220	738745..739191	+	447	WP_004712916.1	DUF2384 domain-containing protein	Antitoxin
CH64_RS03225	739278..739736	+	459	WP_004712918.1	RES family NAD+ phosphorylase	Toxin
CH64_RS03230	739763..740827	-	1065	WP_032815857.1	YcjF family protein	-
CH64_RS03235	740824..742221	-	1398	WP_032815858.1	YcjX family protein	-
CH64_RS03240	742202..742441	-	240	WP_004712923.1	phage shock protein PspD	-
CH64_RS03245	742575..742946	-	372	WP_032815859.1	envelope stress response membrane protein PspC	-
CH64_RS03250	742949..743173	-	225	WP_004712926.1	envelope stress response membrane protein PspB	-
CH64_RS03255	743288..743953	-	666	WP_004712928.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17179.52 Da
• Isoelectric Point: 4.6736

>T49764 WP_004712918.1 NZ_CP009787:739278-739736 [Yersinia rohdei]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMQLQPQ
DWPADWRTDPAPAATMDIGTEWLESQSSLGLLVPSTLVPSENNLLVNPRHPDFQTSLNSAKPLPFVFDPRLK

Nucleotide

• Length: 459 bp

>T49764 NZ_CP009787:739278-739736 [Yersinia rohdei]
ATGATGCTCTACCGCATTGTCATGCGCCGTTATCTTGCCTCAACCTGGACGGGTTATGGTGCAGAAATCTATGGCGGCCG
TTGGAATCATAAAGGGCATGCCGCTATCTACTTAGCCAGCAGCGTATCATTGGCAATGTTAGAAACACTGGTGCATATCC
AAGACAGTTCGACGCTGAGTGAGTTCGAATTATTCCAGATTGAAATCGATGACAGCAATATTATGCAGCTACAACCCCAA
GATTGGCCTGCTGACTGGCGCACTGACCCCGCACCGGCGGCCACTATGGACATCGGTACCGAGTGGCTGGAATCACAATC
ATCGCTTGGATTACTGGTTCCTTCCACTCTGGTACCCTCTGAAAACAATCTGCTGGTTAACCCAAGACACCCAGATTTTC
AGACTAGCTTGAACAGCGCCAAACCACTGCCTTTCGTTTTTGACCCGCGCCTAAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16263.74 Da
• Isoelectric Point: 9.1260

>AT49764 WP_004712916.1 NZ_CP009787:738745-739191 [Yersinia rohdei]
MRAYHPAPATKTGALWREIGLPASRGTLLVDSIKMGFSVDVIDSIHLWAAIPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKSKAIIWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT49764 NZ_CP009787:738745-739191 [Yersinia rohdei]
ATGAGAGCATATCACCCAGCCCCAGCGACCAAAACTGGCGCGCTATGGCGTGAGATTGGTTTGCCCGCCAGCCGCGGCAC
CCTATTGGTAGACAGCATTAAAATGGGATTTTCTGTTGATGTTATCGACAGCATTCATCTATGGGCCGCCATTCCTAAGT
CTGAAATATTGCGCGCCACCGGTATTCCCAGCCGCAGCCTTACCCGCAGGCGCACCCATGATGGCCGCTTCACACCAGAA
GAGAGTGAGCGAATTGCACGTTTTGTTCGCGTAATGGATGCCGCGGTGGACTTGTTCGGGGGCGATAAAAGCAAAGCCAT
TATTTGGATGTCCACCCCGATTAAAGGTTTGGGTCACCGCAGCCCAGATTCTCTACTAGAAACAGAAACTGGCGCACTGG
AAGTCTGTGATTTAATCGGGCGTTTGGAGCACGGTGTATTTTCATAG

Structures

Antitoxin

• AlphaFold DB: A0A0U1HPA3