Detailed information of TA system TA049763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 649547..650304
• Replicon: chromosome
• Accession: NZ_CP009787
• Organism: Yersinia rohdei strain YRA

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CH64_RS02855
• Protein ID: WP_081452069.1
• Coordinates: 649822..650304 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A0U1HPN4
• Locus tag: CH64_RS02850
• Protein ID: WP_004715899.1
• Coordinates: 649547..649831 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH64_RS02825	644978..646387	-	1410	WP_004715893.1	MFS transporter	-
CH64_RS02830	646650..646928	-	279	WP_004715894.1	DUF1471 domain-containing protein	-
CH64_RS02835	647251..647814	+	564	WP_004715896.1	TetR/AcrR family transcriptional regulator	-
CH64_RS02840	647886..648650	+	765	WP_004715897.1	glucose 1-dehydrogenase	-
CH64_RS02845	648778..649461	+	684	WP_004715898.1	epimerase	-
CH64_RS02850	649547..649831	+	285	WP_004715899.1	DUF1778 domain-containing protein	Antitoxin
CH64_RS02855	649822..650304	+	483	WP_081452069.1	GNAT family N-acetyltransferase	Toxin
CH64_RS02860	650571..651923	-	1353	WP_004715901.1	SIR2 family protein	-
CH64_RS02870	652851..654056	-	1206	WP_004715902.1	aldose 1-epimerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (25-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-88)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17915.73 Da
• Isoelectric Point: 7.7993

>T49763 WP_081452069.1 NZ_CP009787:649822-650304 [Yersinia rohdei]
MEMIITAPGLLTEEHILQPFDCGNEVLSDWLRRRAMKNQLQNASRTFVICLDGTTRVVGYYSIATGSVSHANLGRSLRQN
MPDPVPIVLLGRLAVDVCTQGHRFGKWLLNDAVMRISNLADQVGIKAIMVHAIDDQARAFYEYFGFVQSPIASNTLFYKI

Nucleotide

• Length: 483 bp

>T49763 NZ_CP009787:649822-650304 [Yersinia rohdei]
ATGGAAATGATCATTACCGCGCCAGGACTGCTGACAGAAGAGCATATTCTCCAGCCGTTCGACTGCGGAAATGAGGTGCT
GAGTGACTGGTTGCGCCGTCGAGCCATGAAAAACCAGCTCCAGAATGCCTCCCGTACTTTCGTTATCTGTCTGGACGGTA
CAACGCGTGTGGTGGGTTATTACTCCATTGCAACCGGCTCAGTCAGTCACGCCAATTTAGGTCGTAGCCTTCGCCAGAAC
ATGCCAGATCCCGTGCCAATCGTCCTGCTGGGACGTCTGGCTGTCGATGTTTGTACCCAGGGCCATCGCTTTGGCAAATG
GCTTCTTAATGATGCCGTGATGCGAATTTCTAATCTGGCAGACCAAGTGGGTATTAAAGCCATCATGGTGCATGCGATAG
ATGATCAAGCGAGAGCATTCTATGAGTACTTCGGTTTCGTCCAGTCGCCTATCGCTTCGAACACACTCTTCTACAAGATT
TGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11166.74 Da
• Isoelectric Point: 7.0178

>AT49763 WP_004715899.1 NZ_CP009787:649547-649831 [Yersinia rohdei]
MQRTIRKPTRDKQINVRATEEERAVIDYAASLVNKNRTDFIIEKVVHEAQNIILDQRVFVLDDERYQAFIEQLEAPVQNA
EGRKRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT49763 NZ_CP009787:649547-649831 [Yersinia rohdei]
ATGCAGCGTACCATTCGTAAACCCACTCGCGACAAGCAAATTAACGTCCGAGCTACCGAAGAAGAGCGTGCAGTAATCGA
CTATGCTGCGAGTTTGGTCAATAAGAACCGAACCGACTTCATTATTGAGAAGGTTGTTCATGAGGCACAGAACATCATCC
TGGATCAGCGTGTATTCGTCCTTGATGATGAACGCTATCAGGCATTCATTGAACAGCTTGAAGCTCCGGTGCAAAATGCA
GAAGGGCGCAAACGCTTAATGGATGTGAAGCCTGAATGGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0U1HPN4