Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 3995402..3996158 | Replicon | chromosome |
| Accession | NZ_CP009786 | ||
| Organism | Yersinia pseudotuberculosis strain | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A3G5KDU1 |
| Locus tag | BZ23_RS17885 | Protein ID | WP_032467110.1 |
| Coordinates | 3995402..3995770 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | Q664A5 |
| Locus tag | BZ23_RS17890 | Protein ID | WP_011193303.1 |
| Coordinates | 3995823..3996158 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ23_RS17855 | 3990482..3991489 | + | 1008 | WP_011193296.1 | iron chelate uptake ABC transporter family permease subunit | - |
| BZ23_RS17860 | 3991486..3992244 | + | 759 | WP_011193297.1 | ABC transporter ATP-binding protein | - |
| BZ23_RS17865 | 3992241..3992741 | - | 501 | WP_002214364.1 | virulence RhuM family protein | - |
| BZ23_RS17870 | 3992683..3993009 | - | 327 | WP_011193298.1 | hypothetical protein | - |
| BZ23_RS17875 | 3993032..3993439 | - | 408 | WP_024063553.1 | hypothetical protein | - |
| BZ23_RS22410 | 3993674..3993946 | - | 273 | WP_024063554.1 | Arm DNA-binding domain-containing protein | - |
| BZ23_RS17880 | 3994321..3995175 | - | 855 | WP_032467109.1 | DUF4942 domain-containing protein | - |
| BZ23_RS17885 | 3995402..3995770 | - | 369 | WP_032467110.1 | TA system toxin CbtA family protein | Toxin |
| BZ23_RS17890 | 3995823..3996158 | - | 336 | WP_011193303.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BZ23_RS17895 | 3996170..3996649 | - | 480 | WP_011193304.1 | hypothetical protein | - |
| BZ23_RS17900 | 3996832..3997452 | - | 621 | WP_011193305.1 | hypothetical protein | - |
| BZ23_RS17905 | 3997480..3998034 | - | 555 | WP_011193306.1 | hypothetical protein | - |
| BZ23_RS17910 | 3998282..3998962 | - | 681 | WP_042594241.1 | hypothetical protein | - |
| BZ23_RS17915 | 3999016..3999309 | - | 294 | Protein_3426 | ATP-binding protein | - |
| BZ23_RS17920 | 3999974..4000594 | + | 621 | WP_011193309.1 | inovirus Gp2 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3985241..4008824 | 23583 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13723.81 Da Isoelectric Point: 6.4530
>T49762 WP_032467110.1 NZ_CP009786:c3995770-3995402 [Yersinia pseudotuberculosis]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT
Download Length: 369 bp
>T49762 NZ_CP009786:c3995770-3995402 [Yersinia pseudotuberculosis]
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12452.06 Da Isoelectric Point: 6.0555
>AT49762 WP_011193303.1 NZ_CP009786:c3996158-3995823 [Yersinia pseudotuberculosis]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA
Download Length: 336 bp
>AT49762 NZ_CP009786:c3996158-3995823 [Yersinia pseudotuberculosis]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G5KDU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q664A5 |