Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3075796..3076468 Replicon chromosome
Accession NZ_CP009786
Organism Yersinia pseudotuberculosis strain

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag BZ23_RS14005 Protein ID WP_012104676.1
Coordinates 3075796..3076221 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BZ23_RS14010 Protein ID WP_002209939.1
Coordinates 3076202..3076468 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ23_RS13985 3071488..3072006 + 519 WP_002209934.1 flavodoxin FldB -
BZ23_RS13990 3072091..3073548 - 1458 WP_032466588.1 cell envelope integrity protein CreD -
BZ23_RS13995 3073669..3075087 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
BZ23_RS14000 3075098..3075796 - 699 WP_002209937.1 two-component system response regulator CreB -
BZ23_RS14005 3075796..3076221 - 426 WP_012104676.1 protein YgfX Toxin
BZ23_RS14010 3076202..3076468 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BZ23_RS14015 3076785..3077777 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
BZ23_RS14020 3077850..3078347 - 498 WP_002209941.1 DUF2165 family protein -
BZ23_RS14025 3078656..3079357 - 702 WP_012413925.1 hemolysin III family protein -
BZ23_RS14030 3079559..3080662 - 1104 WP_012413926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T49761 WP_012104676.1 NZ_CP009786:c3076221-3075796 [Yersinia pseudotuberculosis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T49761 NZ_CP009786:c3076221-3075796 [Yersinia pseudotuberculosis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCTATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT49761 WP_002209939.1 NZ_CP009786:c3076468-3076202 [Yersinia pseudotuberculosis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT49761 NZ_CP009786:c3076468-3076202 [Yersinia pseudotuberculosis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References