Detailed information of TA system TA049759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2052696..2053696
• Replicon: chromosome
• Accession: NZ_CP009786
• Organism: Yersinia pseudotuberculosis strain

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: BZ23_RS09375
• Protein ID: WP_011192520.1
• Coordinates: 2053238..2053696 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BZ23_RS09370
• Protein ID: WP_002210982.1
• Coordinates: 2052696..2053142 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ23_RS09350	2048284..2049258	-	975	WP_024062894.1	L-Ala-D/L-Glu epimerase	-
BZ23_RS09355	2049421..2049924	+	504	WP_002210984.1	thiol peroxidase	-
BZ23_RS09360	2050177..2050635	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
BZ23_RS09365	2050782..2052359	-	1578	WP_011192519.1	transcriptional regulator TyrR	-
BZ23_RS09370	2052696..2053142	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BZ23_RS09375	2053238..2053696	+	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
BZ23_RS09380	2053706..2054767	-	1062	WP_012413752.1	YcjF family protein	-
BZ23_RS09385	2054764..2056161	-	1398	WP_012105043.1	YcjX family protein	-
BZ23_RS09390	2056142..2056384	-	243	WP_002216375.1	phage shock protein PspD	-
BZ23_RS09395	2056469..2056828	-	360	WP_024062896.1	envelope stress response membrane protein PspC	-
BZ23_RS09400	2056828..2057055	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
BZ23_RS09405	2057217..2057882	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2050177..2050635	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T49759 WP_011192520.1 NZ_CP009786:2053238-2053696 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49759 NZ_CP009786:2053238-2053696 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49759 WP_002210982.1 NZ_CP009786:2052696-2053142 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49759 NZ_CP009786:2052696-2053142 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1