Detailed information of TA system TA049740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3025581..3026547
• Replicon: chromosome
• Accession: NZ_CP009785
• Organism: Yersinia pestis strain El Dorado

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: CH46_RS15215
• Protein ID: WP_002210981.1
• Coordinates: 3025581..3026039 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: CH46_RS15220
• Protein ID: WP_002210982.1
• Coordinates: 3026101..3026547 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH46_RS15185	3021395..3022060	+	666	WP_002210975.1	phage shock protein PspA	-
CH46_RS15190	3022222..3022449	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CH46_RS15195	3022449..3022808	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CH46_RS15200	3022893..3023135	+	243	WP_002216375.1	phage shock protein PspD	-
CH46_RS15205	3023116..3024513	+	1398	WP_002210979.1	YcjX family protein	-
CH46_RS15210	3024510..3025571	+	1062	WP_002210980.1	YcjF family protein	-
CH46_RS15215	3025581..3026039	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
CH46_RS15220	3026101..3026547	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
CH46_RS15225	3026882..3028459	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
CH46_RS15230	3028606..3029064	-	459	WP_042592982.1	IS200/IS605 family transposase	-
CH46_RS15235	3029317..3029820	-	504	WP_002210984.1	thiol peroxidase	-
CH46_RS15240	3029983..3030957	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3028606..3029064	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T49740 WP_002210981.1 NZ_CP009785:c3026039-3025581 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T49740 NZ_CP009785:c3026039-3025581 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT49740 WP_002210982.1 NZ_CP009785:c3026547-3026101 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT49740 NZ_CP009785:c3026547-3026101 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1